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Soy Isoflavones, Vitamin D and Calcium: study protocols

12 study groups took Soy Isoflavones together with Vitamin D and Calcium. These are the doses the studies gave. They are not a recommendation.

Soy Isoflavones: what the research found →

Dose per serving from research: Soy Isoflavones

12 study groups in 8 studies say how much Soy Isoflavones participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 67% of 12 study groups.

Daily doseStudy groups
25 mg to 50 mg
1
50 mg to 100 mg
8
100 mg to 250 mg
3

Dose per serving from research: Vitamin D

5 study groups in 3 studies say how much Vitamin D participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 IU to 250 IU, 80% of 5 study groups.

Daily doseStudy groups
100 IU or less
1
100 IU to 250 IU
4

Dose per serving from research: Calcium

6 study groups in 4 studies say how much Calcium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 50% of 6 study groups.

Daily doseStudy groups
100 mg to 250 mg
1
250 mg to 500 mg
3
500 mg to 1 g
2

Commonly used together

3 of 12 study groups took Soy Isoflavones, Vitamin D and Calcium with something else, but nothing that 3 or more different studies gave.

12 study groups

Study
Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause
2006 · ES (Estromineral serena) · Symptomatic menopausal women with sleep or mood alterations
60 mg—141 mg24 weeks44
Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial
2007 · genistein · Postmenopausal women with osteopenia and femoral-neck BMD below 0.795 g/cm2
54 mg——2 years198
Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: a randomized clinical trial
2013 · Isoflavone supplementation (Iso) · Postmenopausal women; age and other conditions not specified
165 mg——2 years90
Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: a randomized clinical trial
2013 · Combined exercise and isoflavone (ExIso) · Postmenopausal women; age and other conditions not specified
165 mg——2 years87
Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial
2009 · 80 mg soy isoflavones group · Postmenopausal women; described as healthy
80 mg——2 years—
Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial
2009 · 120 mg soy isoflavones group · Postmenopausal women; described as healthy
120 mg——2 years—
Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study
2007 · genistein group · Osteopenic, postmenopausal women; age range not reported
54 mg——2 years198
Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial
2003 · mid-dose · Postmenopausal Chinese women aged 48–62 years
40 mg125 IU500 mg1 year68
Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial
2003 · high dose · Postmenopausal Chinese women aged 48–62 years
80 mg125 IU500 mg1 year68
[Changes of serum lipids after soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-beta genotypes]
2011 · group II · Postmenopausal Chinese women with normal serum lipids and bone loss or osteoporosis
100 mg100 IU440 mg1 year—
Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women
2007 · SPI + EX · Postmenopausal women aged 50–65 years
91.2 mg125 IU900 mg274 days11
Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women
2007 · SPI · Postmenopausal women aged 50–65 years
91.2 mg125 IU900 mg274 days10
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