Soy Isoflavones and Soy Protein: study protocols
29 study groups took Soy Isoflavones together with Soy Protein. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Soy Isoflavones
29 study groups in 26 studies say how much Soy Isoflavones participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 mg to 100 mg, 48% of 29 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg to 50 mg | 6 |
| 50 mg to 100 mg | 14 |
| 100 mg to 250 mg | 9 |
Dose per serving from research: Soy Protein
29 study groups in 26 studies say how much Soy Protein participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 g to 25 g, 52% of 29 study groups.
| Daily dose | Study groups |
|---|---|
| 10 g to 25 g | 15 |
| 25 g to 50 g | 13 |
| over 50 g | 1 |
Commonly used together
6 of 29 study groups took Soy Isoflavones and Soy Protein with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Fiber | 3 |
29 study groups
| Study | ||||
|---|---|---|---|---|
| Impact of a soy drink on climacteric symptoms: an open-label, crossover, randomized clinical trial 2016 · ViveSoy® phase · Peri- or postmenopausal women aged 45 years or older with climacteric symptoms | 50 mg | 15 g | 12 weeks | 90 |
| Soy Protein Containing Isoflavones Improves Facial Signs of Photoaging and Skin Hydration in Postmenopausal Women: Results of a Prospective Randomized Double-Blind Controlled Trial 2023 · SPII (soy protein containing isoflavones) · Healthy postmenopausal women aged 50–70 with Fitzpatrick skin types I–III | 50 mg | 30 g | 24 weeks | 23 |
| Metabolic effects of soy supplementation in postmenopausal Caucasian and African American women: a randomized, placebo-controlled trial 2010 · soy supplement · Postmenopausal women aged 45–60 with obesity (BMI 30–40 kg/m²), without diabetes; Caucasian and African American participants | 160 mg | 20 g | 90 days | 17 |
| Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women 2007 · Soy shake · Postmenopausal women aged 55.6 ± 1.4 years with BMI 30.5 ± 0.8 kg/m² and no diabetes | 160 mg | 20 g | 90 days | 9 |
| A mild favorable effect of soy protein with isoflavones on body composition--a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women 2010 · Soy group · Chinese postmenopausal women with mild hyperglycemia; age range not reported | 100 mg | 15 g | 26 weeks | — |
| Effect of soy nuts and equol status on blood pressure, lipids and inflammation in postmenopausal women stratified by metabolic syndrome status 2015 · TLC diet with soy nuts · Healthy postmenopausal women, with and without metabolic syndrome; no atherosclerosis or diabetes | 101 mg | 25 g | 8 weeks | 60 |
| The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women 2001 · Soy+ group · Postmenopausal women with moderate hypercholesterolemia | 80 mg | 42 g | 12 weeks | 31 |
| Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects 2001 · Abalon · Adults with type 2 diabetes | 165 mg | 50 g | 6 weeks | — |
| Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects 2005 · soy supplement (Abalon) · Hypercholesterolaemic but otherwise healthy adults; age range and sex not stated | 100 mg | 30 g | 24 weeks | — |
| The effect on the blood lipid profile of soy foods combined with a prebiotic: a randomized controlled trial 2010 · soy food-containing diet · Hyperlipidemic adults; mean age 58 ± 7 years; 11 men and 12 women | 61 mg | 30 g | 4 weeks | — |
| The effect on the blood lipid profile of soy foods combined with a prebiotic: a randomized controlled trial 2010 · soy food-containing diet with prebiotic · Hyperlipidemic adults; mean age 58 ± 7 years; 11 men and 12 women | 61 mg | 30 g | 4 weeks | — |
| Effect of soy protein and isoflavones on blood pressure and endothelial cytokines: a 6-month randomized controlled trial among postmenopausal women 2013 · Soy group · Postmenopausal Chinese women with mild hyperglycemia; subgroup analysis included women with prehypertension or hypertension | 100 mg | 15 g | 26 weeks | — |
| Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause 2018 · soy protein with isoflavones (SPI) · Women in the early menopause, mean age 55 years | 66 mg | 15 g | 26 weeks | — |
| Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland 2004 · soy-containing diet group · Men aged 45 to 59 with relatively higher blood pressure and/or total cholesterol levels | 80 mg | 20 g | 5 weeks | — |
| Equol production changes over time in postmenopausal women 2012 · soy group · Postmenopausal women, predominantly Caucasian; no specific disease stated. | 90 mg | 25 g | 913 days | 175 |
| Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - a randomised controlled study 2017 · SPI group · Men aged 45–75 with type 2 diabetes, low testosterone and normal FSH and LH | 66 mg | 15 g | 90 days | 100 |
| Soy-tibolone combination - effect on lipids in postmenopausal monkeys and women 2008 · soy powder · Postmenopausal women, mean age 57.7 years, with or without daidzein-to-equol conversion capability, treated with tibolone | 112 mg | 52 g | 8 weeks | 40 |
| Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes 2002 · phytoestrogen supplementation · Postmenopausal women with diet-controlled type 2 diabetes | 132 mg | 30 g | 12 weeks | 32 |
| Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal women 2009 · soy protein / isoflavone group · Postmenopausal women, mean age 57 years, without diabetes or other specified excluded conditions | 160 mg | 20 g | 12 weeks | 32 |
| Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity--a controlled crossover trial 2000 · Test diet · Adults with hyperlipidemia; age and sex not specified | 86 mg | 33 g | 30 days | 31 |
| Effect of soy-based breakfast cereal on blood lipids and oxidized low-density lipoprotein 2000 · soy breakfast cereal · Hyperlipidemic men and women; ages and sex distribution not reported | 168 mg | 36 g | 3 weeks | 25 |
| Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women 1999 · 20 g soy protein containing 34 mg of phytoestrogens given in a single dose · Perimenopausal women; age range and specific conditions not stated | 34 mg | 20 g | 6 weeks | — |
| Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women 1999 · 20 g of soy protein containing 34 mg of phytoestrogens split into two doses · Perimenopausal women; age range and specific conditions not stated | 34 mg | 20 g | 6 weeks | — |
| The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption 2005 · soy protein · Postmenopausal women, including breast cancer survivors and controls | 44.4 mg | 26.6 g | 6 weeks | — |
| Effects of soy bean on serum paraoxonase 1 activity and lipoproteins in hyperlipidemic postmenopausal women 2009 · soy group · Hypercholesterolemic postmenopausal women | 164 mg | 50 g | 10 weeks | — |
| Effect of soybean protein on novel cardiovascular disease risk factors: a randomized controlled trial 2013 · soy protein · Men and women aged 22 years or older with mean systolic blood pressure 120–159 mm Hg and diastolic blood pressure 80–95 mm Hg | 89.3 mg | 40 g | 8 weeks | — |
| Soy Reduces Bone Turnover Markers in Women During Early Menopause: A Randomized Controlled Trial 2017 · soy protein with isoflavone (SPI) · Women within 2 years after the onset of menopause | 66 mg | 15 g | 26 weeks | — |
| Effect of Soy in Men With Type 2 Diabetes Mellitus and Subclinical Hypogonadism: A Randomized Controlled Study 2017 · Soy protein with isoflavones (SPI) · Men with type 2 diabetes mellitus and total testosterone ≤12 nmol/L | 66 mg | 15 g | 90 days | — |
| The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption 2005 · soy protein + probiotics · Postmenopausal women, including breast cancer survivors and controls | 44.4 mg | 26.6 g | 6 weeks | — |