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Soy Isoflavones and Calcium: study protocols

24 study groups took Soy Isoflavones together with Calcium. These are the doses the studies gave. They are not a recommendation.

Soy Isoflavones: what the research found →

Dose per serving from research: Soy Isoflavones

24 study groups in 16 studies say how much Soy Isoflavones participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 71% of 24 study groups.

Daily doseStudy groups
25 mg to 50 mg
3
50 mg to 100 mg
17
100 mg to 250 mg
4

Dose per serving from research: Calcium

17 study groups in 12 studies say how much Calcium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 76% of 17 study groups.

Daily doseStudy groups
100 mg to 250 mg
2
250 mg to 500 mg
13
500 mg to 1 g
2

Commonly used together

16 of 24 study groups took Soy Isoflavones and Calcium with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin D
12

24 study groups

Study
Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause
2006 · ES (Estromineral serena) · Symptomatic menopausal women with sleep or mood alterations
60 mg141 mg24 weeks44
The soy isoflavones for reducing bone loss study: 3-yr effects on pQCT bone mineral density and strength measures in postmenopausal women
2011 · 80 mg of isoflavones · Postmenopausal women aged 46.1–63.1 years, 0.8–7.88 years since last menstrual period, without diagnosed chronic disease
80 mg500 mg3 years—
The soy isoflavones for reducing bone loss study: 3-yr effects on pQCT bone mineral density and strength measures in postmenopausal women
2011 · 120 mg of isoflavones · Postmenopausal women aged 46.1–63.1 years, 0.8–7.88 years since last menstrual period, without diagnosed chronic disease
120 mg500 mg3 years—
Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial
2007 · genistein · Postmenopausal women with osteopenia and femoral-neck BMD below 0.795 g/cm2
54 mg—2 years198
Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: a randomized clinical trial
2013 · Isoflavone supplementation (Iso) · Postmenopausal women; age and other conditions not specified
165 mg—2 years90
Effect of exercise training combined with isoflavone supplementation on bone and lipids in postmenopausal women: a randomized clinical trial
2013 · Combined exercise and isoflavone (ExIso) · Postmenopausal women; age and other conditions not specified
165 mg—2 years87
[Relationship between estrogen receptor gene Px haplotype and the effect of calcium and soy isoflavone supplementation on bone mineral density of Chinese postmenopausal women]
2008 · Ca + soy isoflavone group · Chinese postmenopausal women aged 45–65 with baseline BMD T score < -1.5
100 mg440 mg1 year26
Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial
2009 · 80 mg soy isoflavones group · Postmenopausal women; described as healthy
80 mg—2 years—
Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial
2009 · 120 mg soy isoflavones group · Postmenopausal women; described as healthy
120 mg—2 years—
Effect of Lactobacillus sporogenes on oral isoflavones bioavailability: single dose pharmacokinetic study in menopausal women
2011 · R (reference formulation) · Menopausal women, mean age 54.3 years, receiving antibiotic therapy
60 mg—1 day12
Effect of Lactobacillus sporogenes on oral isoflavones bioavailability: single dose pharmacokinetic study in menopausal women
2011 · E (Estromineral test formulation) · Menopausal women, mean age 54.3 years, receiving antibiotic therapy
60 mg141 mg1 day12
Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study
2007 · genistein group · Osteopenic, postmenopausal women; age range not reported
54 mg—2 years198
Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial
2003 · mid-dose · Postmenopausal Chinese women aged 48–62 years
40 mg500 mg1 year68
Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial
2003 · high dose · Postmenopausal Chinese women aged 48–62 years
80 mg500 mg1 year68
Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial
2004 · mid-dose · Postmenopausal Chinese women aged 48 to 62 years
40 mg500 mg1 year68
Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial
2004 · high-dose · Postmenopausal Chinese women aged 48 to 62 years
80 mg500 mg1 year68
Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial
2007 · 40 mg isoflavones · Postmenopausal Chinese women aged 48 to 62 years
40 mg500 mg1 year68
Soy isoflavone supplementation and fasting serum glucose and lipid profile among postmenopausal Chinese women: a double-blind, randomized, placebo-controlled trial
2007 · 80 mg isoflavones · Postmenopausal Chinese women aged 48 to 62 years
80 mg500 mg1 year68
The hypoglycemic effects of soy isoflavones on postmenopausal women
2004 · isoflavone group · Postmenopausal Taiwanese women
100 mg300 mg26 weeks—
[Changes of serum lipids after soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-beta genotypes]
2011 · group II · Postmenopausal Chinese women with normal serum lipids and bone loss or osteoporosis
100 mg440 mg1 year—
Effect of soy isoflavone supplementation on vascular endothelial function and oxidative stress in postmenopausal women: a community randomized controlled trial
2013 · intervention group · Indonesian postmenopausal women aged 47 to 60 years
100 mg500 mg1 year—
Effect of soy isoflavone supplementation on endothelial dysfunction and oxidative stress in equol-producing postmenopausal women
2015 · Intervention group · Postmenopausal Indonesian women aged 47–60 years, stratified by equol-producer status
100 mg500 mg26 weeks—
Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women
2007 · SPI + EX · Postmenopausal women aged 50–65 years
91.2 mg900 mg274 days11
Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women
2007 · SPI · Postmenopausal women aged 50–65 years
91.2 mg900 mg274 days10
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