Riboflavin, Folic Acid, Vitamin B6 and Vitamin B12: study protocols
9 study groups took Riboflavin together with Folic Acid, Vitamin B6 and Vitamin B12. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Riboflavin
9 study groups in 8 studies say how much Riboflavin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 56% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mcg or less | 1 |
| 500 mcg to 1 mg | 0 |
| 1 mg to 2.5 mg | 5 |
| 2.5 mg to 5 mg | 1 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 2 |
Dose per serving from research: Folic Acid
9 study groups in 8 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 44% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 3 |
| 250 mcg to 500 mcg | 4 |
| 500 mcg to 1 mg | 2 |
Dose per serving from research: Vitamin B6
9 study groups in 8 studies say how much Vitamin B6 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 33% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mcg or less | 1 |
| 500 mcg to 1 mg | 0 |
| 1 mg to 2.5 mg | 3 |
| 2.5 mg to 5 mg | 2 |
| 5 mg to 10 mg | 1 |
| 10 mg to 25 mg | 2 |
Dose per serving from research: Vitamin B12
9 study groups in 8 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 33% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mcg or less | 1 |
| 1 mcg to 2.5 mcg | 1 |
| 2.5 mcg to 5 mcg | 3 |
| 5 mcg to 10 mcg | 2 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 2 |
Commonly used together
8 of 9 study groups took Riboflavin, Folic Acid, Vitamin B6 and Vitamin B12 with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Thiamine | 5 |
| Vitamin E | 5 |
| Zinc | 5 |
| Iron | 4 |
| Vitamin A | 4 |
| Vitamin C | 4 |
| Vitamin D | 4 |
| Copper | 3 |
| Iodine | 3 |
| Niacin | 3 |
9 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 1.8 mg | 400 mcg | 2.2 mg | 2.6 mcg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women | 20 mg | 800 mcg | 25 mg | 50 mcg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women | 20 mg | 800 mcg | 25 mg | 50 mcg | — | — |
| A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status 2022 · B-vitamin treatment · Community-dwelling adults aged 50 years or older; men and women; no specific diagnosed condition, and not currently taking B-vitamin supplements at screening | 5 mg | 200 mcg | 10 mg | 10 mcg | 2 years | 103 |
| Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial 2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception | 1.8 mg | 400 mcg | 2.6 mg | 5.2 mcg | — | 870 |
| Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial 2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies | 500 mcg | 150 mcg | 500 mcg | 0.9 mcg | 36 weeks | 130 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 1.4 mg | 400 mcg | 1.9 mg | 2.6 mcg | 12 weeks | 105 |
| Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial 2016 · Normocis 400® group · Adults with stage 1 essential hypertension and hyper-homocysteinemia (HCys ≥15 μmol/L), without a history of cardiovascular or cerebrovascular disease; mean age 62.8 years, 63.5% male | 2.4 mg | 400 mcg | 3 mg | 5 mcg | 60 days | 52 |
| Effects of mixed dietary supplements on total plasma homocysteine concentrations (tHcy): a randomized, double-blind, placebo-controlled trial 2012 · supplement group · hospitalized, acutely ill older patients recovering from acute illness; sex and age range not stated | 1.3 mg | 200 mcg | 1.4 mg | 1.5 mcg | 6 weeks | — |