Iron and Folic Acid: study protocols
170 study groups took Iron together with Folic Acid. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Iron
165 study groups in 84 studies say how much Iron participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 mg to 100 mg, 42% of 165 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 18 |
| 10 mg to 25 mg | 22 |
| 25 mg to 50 mg | 50 |
| 50 mg to 100 mg | 69 |
| over 100 mg | 5 |
Dose per serving from research: Folic Acid
149 study groups in 74 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 71% of 149 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mcg or less | 6 |
| 50 mcg to 100 mcg | 10 |
| 100 mcg to 250 mcg | 19 |
| 250 mcg to 500 mcg | 106 |
| 500 mcg to 1 mg | 4 |
| over 1 mg | 4 |
Commonly used together
78 of 170 study groups took Iron and Folic Acid with something else. Shown: what 3 or more different studies gave. The 10 most common of 15.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Zinc | 31 |
| Vitamin A | 30 |
| Vitamin C | 23 |
| Vitamin B12 | 18 |
| Iodine | 16 |
| Copper | 14 |
| Selenium | 13 |
| Vitamin D | 13 |
| Vitamin E | 13 |
| Niacin | 11 |
170 study groups
| Study | ||||
|---|---|---|---|---|
| Effect of prenatal zinc supplementation on birthweight 2009 · Control group · Pregnant women recruited by 16 weeks’ gestation in Ghana; age range 16–44 years; no stated diagnosed condition, with women taking other zinc supplements or with severe anaemia excluded. | 20 mg | 200 mcg | — | 301 |
| Effect of prenatal zinc supplementation on birthweight 2009 · Iron-zinc group · Pregnant women recruited by 16 weeks’ gestation in Ghana; age range 16–44 years; no stated diagnosed condition, with women taking other zinc supplements or with severe anaemia excluded. | 20 mg | 200 mcg | — | 299 |
| Effects of prenatal micronutrients supplementation timing on pregnancy-induced hypertension: Secondary analysis of a double-blind randomized controlled trial 2021 · IFA group · Pregnant nulliparous Chinese women aged 20 or older, enrolled before 20 gestational weeks, with haemoglobin above 10.0 g/dl | 30 mg | 400 mcg | — | 6,252 |
| Micronutrient supplementation during pregnancy and the risk of pregnancy-induced hypertension: A randomized clinical trial 2019 · IFA group · Nulliparous pregnant women aged 20 years or older, enrolled before 20 weeks of gestation, with hemoglobin at least 10.0 g/dL | 30 mg | 400 mcg | — | 5,933 |
| Effects of Prenatal Micronutrient Supplementation on Spontaneous Preterm Birth: A Double-Blind Randomized Controlled Trial in China 2017 · IFA group · Pregnant women aged 20 years or older, nulliparous, enrolled before 20 gestational weeks, with hemoglobin above 10.0 g/dL | 30 mg | 400 mcg | — | 5,920 |
| Micronutrient supplementation during pregnancy and the risk of pregnancy-induced hypertension: A randomized clinical trial 2019 · MMN group · Nulliparous pregnant women aged 20 years or older, enrolled before 20 weeks of gestation, with hemoglobin at least 10.0 g/dL | 30 mg | 400 mcg | — | 5,914 |
| Effects of Prenatal Micronutrient Supplementation on Spontaneous Preterm Birth: A Double-Blind Randomized Controlled Trial in China 2017 · MMN group · Pregnant women aged 20 years or older, nulliparous, enrolled before 20 gestational weeks, with hemoglobin above 10.0 g/dL | 30 mg | 400 mcg | — | 5,910 |
| Excess risk of preterm birth with periconceptional iron supplementation in a malaria endemic area: analysis of secondary data on birth outcomes in a double blind randomized controlled safety trial in Burkina Faso 2019 · weekly iron and folic acid · Nulliparous, non-pregnant women aged 15–24 years in a malaria-endemic area of Burkina Faso who became pregnant during or shortly after supplementation | 8.57 mg | 400 mcg | 548 days | 980 |
| Cost-effectiveness of invitation to food supplementation early in pregnancy combined with multiple micronutrients on infant survival: analysis of data from MINIMat randomized trial, Bangladesh 2015 · EMMS · Pregnant women in rural Bangladesh, irrespective of nutritional status | 30 mg | 400 mcg | — | 740 |
| Multivitamin and iron supplementation to prevent periconceptional anemia in rural tanzanian women: a randomized, controlled trial 2015 · Folic acid + iron · Non-pregnant women and adolescent girls aged 15–29 years in rural Tanzania | 30 mg | 400 mcg | 26 weeks | 267 |