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Folic Acid and Vitamin B12: study protocols

60 study groups took Folic Acid together with Vitamin B12. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

60 study groups in 49 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 33% of 60 study groups.

Daily doseStudy groups
100 mcg or less
1
100 mcg to 250 mcg
7
250 mcg to 500 mcg
20
500 mcg to 1 mg
17
1 mg to 2.5 mg
6
2.5 mg to 5 mg
7
over 5 mg
2

Dose per serving from research: Vitamin B12

53 study groups in 45 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 30% of 53 study groups.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
4
2.5 mcg to 5 mcg
10
5 mcg to 10 mcg
7
10 mcg to 25 mcg
0
25 mcg to 50 mcg
2
50 mcg to 100 mcg
0
100 mcg to 250 mcg
0
250 mcg to 500 mcg
16
500 mcg to 1 mg
10
1 mg to 2.5 mg
1
over 2.5 mg
2

Commonly used together

47 of 60 study groups took Folic Acid and Vitamin B12 with something else. Shown: what 3 or more different studies gave. The 10 most common of 14.

What was given together, not what works together.

Taken withStudy groups
Vitamin B6
35
Iron
19
Zinc
15
Vitamin A
13
Vitamin C
12
Riboflavin
11
Vitamin E
11
Vitamin D
10
Copper
8
Iodine
8

60 study groups

Study
Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12064 myocardial infarction survivors
2007 · Homocysteine-lowering group · Myocardial infarction survivors
2 mg1 mg6 years—
Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial
2012 · B-vitamins group · Adults with a stroke or transient ischaemic attack within the previous 7 months; men and women, age not restricted
2 mg500 mcg1241 days4,040
Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study
2009 · folic acid/B6/B12 group · Women at high risk of cardiovascular disease, with preexisting cardiovascular disease or at least three coronary risk factors; women included in these AMD analyses had no AMD diagnosis at baseline.
2.5 mg1 mg2665 days2,607
Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial
2008 · combined folic acid/vitamin B6/vitamin B12 treatment · Women aged 40 years or older with a history of cardiovascular disease or at least three coronary risk factors
2.5 mg1 mg2666 days—
Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial
2009 · vitamin therapy group · Adults with known cardiovascular disease
2.5 mg1 mg5 years—
Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial
2019 · B vitamins · B-PROOF trial participants; age and specific condition not stated in the abstract
400 mcg500 mcg3 years—
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg2.6 mcg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg2.6 mcg——
Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial
2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation
400 mcg2.6 mcg——
Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial
2002 · homocysteine-lowering therapy · Patients with coronary artery disease after successful percutaneous coronary intervention; age and sex not specified
1 mg400 mcg26 weeks272
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