Folic Acid, Vitamin B12 and Vitamin A: study protocols
16 study groups took Folic Acid together with Vitamin B12 and Vitamin A. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Folic Acid
16 study groups in 13 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 63% of 16 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg or less | 1 |
| 100 mcg to 250 mcg | 2 |
| 250 mcg to 500 mcg | 10 |
| 500 mcg to 1 mg | 3 |
Dose per serving from research: Vitamin B12
16 study groups in 13 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 56% of 16 study groups.
| Daily dose | Study groups |
|---|---|
| 0.5 mcg or less | 1 |
| 0.5 mcg to 1 mcg | 1 |
| 1 mcg to 2.5 mcg | 2 |
| 2.5 mcg to 5 mcg | 9 |
| 5 mcg to 10 mcg | 0 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 1 |
| 50 mcg to 100 mcg | 0 |
| 100 mcg to 250 mcg | 0 |
| 250 mcg to 500 mcg | 0 |
| 500 mcg to 1 mg | 0 |
| 1 mg to 2.5 mg | 0 |
| 2.5 mg to 5 mg | 0 |
| 5 mg to 10 mg | 2 |
Dose per serving from research: Vitamin A
12 study groups in 10 studies say how much Vitamin A participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mcg to 1 mg, 75% of 12 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mcg or less | 1 |
| 250 mcg to 500 mcg | 2 |
| 500 mcg to 1 mg | 9 |
Commonly used together
16 of 16 study groups took Folic Acid, Vitamin B12 and Vitamin A with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Iron | 14 |
| Vitamin E | 13 |
| Vitamin B6 | 12 |
| Vitamin C | 12 |
| Zinc | 12 |
| Copper | 11 |
| Vitamin D | 11 |
| Iodine | 10 |
| Niacin | 10 |
| Selenium | 10 |
16 study groups
| Study | |||||
|---|---|---|---|---|---|
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 400 mcg | 2.6 mcg | 800 mcg | — | — |
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 400 mcg | 2.6 mcg | 800 mcg | — | — |
| Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial 2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation | 400 mcg | 2.6 mcg | 800 mcg | — | — |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 400 mcg | 2.6 mcg | 1 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women | 800 mcg | 50 mcg | 5,000 IU | — | — |
| Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam 2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant | 400 mcg | 0.371 mcg | 114 mcg | 54 weeks | 1,469 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 400 mcg | 2.6 mcg | 800 mcg | 180 days | 516 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 400 mcg | 2.6 mcg | 800 mcg | 180 days | 515 |
| Associations of maternal nutrition during pregnancy and post-partum with maternal cognition and caregiving 2018 · MMN · Pregnant women enrolled at ≤20 weeks’ gestation in Malawi, followed through 6 months postpartum | 400 mcg | 5.2 mg | — | 1 year | 239 |
| Associations of maternal nutrition during pregnancy and post-partum with maternal cognition and caregiving 2018 · LNS · Pregnant women enrolled at ≤20 weeks’ gestation in Malawi, followed through 6 months postpartum | 400 mcg | 5.2 mg | — | 1 year | 234 |