Folic Acid, Vitamin B12 and Vitamin B6: study protocols
52 study groups took Folic Acid together with Vitamin B12 and Vitamin B6. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Folic Acid
52 study groups in 49 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mcg to 1 mg, 33% of 52 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg or less | 1 |
| 100 mcg to 250 mcg | 3 |
| 250 mcg to 500 mcg | 14 |
| 500 mcg to 1 mg | 17 |
| 1 mg to 2.5 mg | 10 |
| 2.5 mg to 5 mg | 6 |
| over 5 mg | 1 |
Dose per serving from research: Vitamin B12
50 study groups in 47 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 44% of 50 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mcg or less | 2 |
| 1 mcg to 2.5 mcg | 2 |
| 2.5 mcg to 5 mcg | 10 |
| 5 mcg to 10 mcg | 4 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 2 |
| 50 mcg to 100 mcg | 0 |
| 100 mcg to 250 mcg | 0 |
| 250 mcg to 500 mcg | 22 |
| 500 mcg to 1 mg | 8 |
Dose per serving from research: Vitamin B6
51 study groups in 48 studies say how much Vitamin B6 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 25% of 51 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mg or less | 2 |
| 1 mg to 2.5 mg | 12 |
| 2.5 mg to 5 mg | 5 |
| 5 mg to 10 mg | 6 |
| 10 mg to 25 mg | 13 |
| 25 mg to 50 mg | 12 |
| over 50 mg | 1 |
Commonly used together
20 of 52 study groups took Folic Acid, Vitamin B12 and Vitamin B6 with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Riboflavin | 13 |
| Vitamin C | 13 |
| Vitamin E | 13 |
| Vitamin A | 12 |
| Vitamin D | 12 |
| Zinc | 12 |
| Iron | 11 |
| Copper | 10 |
| Iodine | 10 |
| Niacin | 10 |
52 study groups
| Study | |||||
|---|---|---|---|---|---|
| Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial 2012 · B-vitamins group · Adults with a stroke or transient ischaemic attack within the previous 7 months; men and women, age not restricted | 2 mg | 500 mcg | 25 mg | 1241 days | 4,040 |
| Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study 2009 · folic acid/B6/B12 group · Women at high risk of cardiovascular disease, with preexisting cardiovascular disease or at least three coronary risk factors; women included in these AMD analyses had no AMD diagnosis at baseline. | 2.5 mg | 1 mg | 50 mg | 2665 days | 2,607 |
| Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial 2008 · combined folic acid/vitamin B6/vitamin B12 treatment · Women aged 40 years or older with a history of cardiovascular disease or at least three coronary risk factors | 2.5 mg | 1 mg | 50 mg | 2666 days | — |
| Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial 2009 · vitamin therapy group · Adults with known cardiovascular disease | 2.5 mg | 1 mg | 50 mg | 5 years | — |
| B-vitamins reduce the long-term risk of depression after stroke: The VITATOPS-DEP trial 2010 · B-vitamins · Stroke survivors; age and sex not specified | 2 mg | 500 mcg | 25 mg | 383 days | — |
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 400 mcg | 2.6 mcg | 1.9 mg | — | — |
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 400 mcg | 2.6 mcg | 1.9 mg | — | — |
| Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial 2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation | 400 mcg | 2.6 mcg | 1.9 mg | — | — |
| Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial 2002 · homocysteine-lowering therapy · Patients with coronary artery disease after successful percutaneous coronary intervention; age and sex not specified | 1 mg | 400 mcg | 10 mg | 26 weeks | 272 |
| 5-methyltetrahydrofolate administration is associated with prolonged survival and reduced inflammation in ESRD patients 2008 · group B · Hemodialysis patients with end-stage renal disease; age and sex not reported | 5 mg | — | — | — | — |