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Cocoa Extract: study protocols

10 study groups say how much Cocoa Extract participants took a day. These are the doses the studies gave. They are not a recommendation.

Cocoa Extract: what the research found →

Dose per serving from products

55 products in our catalogue print how much Cocoa Extract a serving holds.

Most common: 50 mg to 100 mg and 1 g to 2.5 g, 20% of 55 products each.

Dose per servingProducts
10 mg or less
1
10 mg to 25 mg
8
25 mg to 50 mg
5
50 mg to 100 mg
11
100 mg to 250 mg
9
250 mg to 500 mg
3
500 mg to 1 g
4
1 g to 2.5 g
11
2.5 g to 5 g
3

Dose per serving from research

10 study groups in 5 studies say how much Cocoa Extract participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 80% of 10 study groups.

Daily doseStudy groups
250 mg to 500 mg
8
500 mg to 1 g
2

Commonly used together

4 of 10 study groups took Cocoa Extract with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Multivitamin
4

10 study groups

Study
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
2022 · active cocoa extract and multivitamin placebo · Women aged 65 years or older and men aged 60 years or older, without recent myocardial infarction, stroke, or cancer (except nonmelanoma skin cancer)
500 mg1314 days—
The overlooked impact of background diet and adherence in nutrition trials
2025 · Cocoa extract intervention · Men aged 60 years or older and women aged 65 years or older in the United States
500 mg1314 days—
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
2022 · active cocoa extract and active multivitamin · Women aged 65 years or older and men aged 60 years or older, without recent myocardial infarction, stroke, or cancer (except nonmelanoma skin cancer)
500 mg1314 days—
Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial
2018 · DP1–10 · Healthy Caucasian men aged 18–35 years
690 mg30 days15
Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial
2018 · DP2–10 · Healthy Caucasian men aged 18–35 years
560 mg30 days15
Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial
2023 · Cocoa extract only (Groups 2; cocoa extract plus multivitamin in Group 4) · Adults aged 65 years or older from the general population
500 mg3 years—
Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial
2023 · Cocoa extract plus multivitamin-mineral (Group 4) · Adults aged 65 years or older from the general population
500 mg3 years—
Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial
2025 · Cocoa extract group · Women aged 65 years or older and men aged 60 years or older
500 mg2 years—
The overlooked impact of background diet and adherence in nutrition trials
2025 · Cocoa extract plus multivitamin intervention · Men aged 60 years or older and women aged 65 years or older in the United States
500 mg1314 days—
Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial
2025 · Cocoa extract plus multivitamin group · Women aged 65 years or older and men aged 60 years or older
500 mg2 years—