Choline and Vitamin B12: study protocols
5 study groups took Choline together with Vitamin B12. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Choline
5 study groups in 4 studies say how much Choline participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 100% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mg to 500 mg | 5 |
Dose per serving from research: Vitamin B12
5 study groups in 4 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 60% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mcg to 5 mcg | 3 |
| 5 mcg to 10 mcg | 0 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 0 |
| 50 mcg to 100 mcg | 1 |
| 100 mcg to 250 mcg | 0 |
| 250 mcg to 500 mcg | 0 |
| 500 mcg to 1 mg | 1 |
Commonly used together
5 of 5 study groups took Choline and Vitamin B12 with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Docosahexaenoic Acid | 4 |
| Selenium | 4 |
5 study groups
| Study | ||||
|---|---|---|---|---|
| Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease 2015 · Active group (RCT1, RCT2 and RCT3) · Men and women aged 50 years or older with mild or mild-to-moderate Alzheimer's disease; RCT3 participants were on stable approved Alzheimer's medication, while RCT1 and RCT2 participants were drug-free for Alzheimer's medication. | 400 mg | 3 mcg | 24 weeks | 501 |
| Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease 2015 · Active product during open-label extension (OLE) · Men and women aged 50 years or older with mild Alzheimer's disease who completed RCT2. | 400 mg | 3 mcg | 24 weeks | 201 |
| Assessment of vitamin A, vitamin B(2), vitamin B(12), vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial 2025 · INT (intervention group; standard and double omega-3 dosage subgroups) · Healthy adults aged 18 years or older who had followed a vegan diet for at least 1 year; no diagnosed vitamin or mineral deficiency | 300 mg | 100 mcg | 120 days | 35 |
| Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial 2024 · intervention group · Adults aged 18–70 with obesity and dyslipidemia | 500 mg | 1 mg | 90 days | 105 |
| The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer's disease: results from a randomized controlled trial 2017 · Test product (Souvenaid/Fortasyn Connect) · Adults aged 50 years or older with mild probable or possible Alzheimer’s disease | 400 mg | 3 mcg | 4 weeks | 16 |