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Calcium, Vitamin B12, Vitamin B6 and Folic Acid: study protocols

8 study groups took Calcium together with Vitamin B12, Vitamin B6 and Folic Acid. These are the doses the studies gave. They are not a recommendation.

Calcium: what the research found →

Dose per serving from research: Calcium

8 study groups in 8 studies say how much Calcium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg and 500 mg to 1 g, 38% of 8 study groups each.

Daily doseStudy groups
100 mg to 250 mg
2
250 mg to 500 mg
3
500 mg to 1 g
3

Dose per serving from research: Vitamin B12

7 study groups in 7 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 57% of 7 study groups.

Daily doseStudy groups
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
0
5 mcg to 10 mcg
2
10 mcg to 25 mcg
0
25 mcg to 50 mcg
0
50 mcg to 100 mcg
0
100 mcg to 250 mcg
0
250 mcg to 500 mcg
4

Dose per serving from research: Vitamin B6

8 study groups in 8 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 50% of 8 study groups.

Daily doseStudy groups
500 mcg to 1 mg
2
1 mg to 2.5 mg
1
2.5 mg to 5 mg
1
5 mg to 10 mg
0
10 mg to 25 mg
0
25 mg to 50 mg
4

Dose per serving from research: Folic Acid

7 study groups in 7 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 71% of 7 study groups.

Daily doseStudy groups
250 mcg or less
1
250 mcg to 500 mcg
5
500 mcg to 1 mg
1

Commonly used together

8 of 8 study groups took Calcium, Vitamin B12, Vitamin B6 and Folic Acid with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin D
5

8 study groups

Study
Lower rate of preeclampsia after antioxidant supplementation in pregnant women with low antioxidant status
2006 · supplementation group · Pregnant women screened positive for low antioxidant status at 8 to 12 weeks of gestation
800 mg—2.2 mg——29
Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance
2014 · B vitamin supplementation group · Healthy preschool children selected for low urinary folate-status ranking
130 mg1.2 mcg730 mcg220 mcg90 days—
One year B-vitamins increases serum and whole blood folate forms and lowers plasma homocysteine in older Germans
2015 · B-vitamin supplementation · Older German adults, mean age 67 years
456 mg500 mcg50 mg500 mcg1 year—
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
150 mg5.2 mcg2.6 mg400 mcg—870
Mineral water fortified with folic acid, vitamins B6, B12, D and calcium improves folate status and decreases plasma homocysteine concentration in men and women
2004 · Fortified mineral water · Free-living men and women without folate deficiency or elevated homocysteine
563 mg7.5 mcg1 mg563 mcg8 weeks—
Plasma trimethylamine-N-oxide following supplementation with vitamin D or D plus B vitamins
2017 · vitamin D + B arm · Participants; age, sex, and health condition not specified
800 mg500 mcg50 mg500 mcg1 year25
One year B and D vitamins supplementation improves metabolic bone markers
2013 · group A · Healthy adults older than 54 years
456 mg500 mcg50 mg500 mcg1 year—
One-carbon metabolites and telomere length in a prospective and randomized study of B- and/or D-vitamin supplementation
2017 · group A · Adults older than 54 years; no specific condition stated
456 mg500 mcg50 mg500 mcg1 year—
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