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Branched-Chain Amino Acids and Leucine: study protocols

17 study groups took Branched-Chain Amino Acids together with Leucine. These are the doses the studies gave. They are not a recommendation.

Branched-Chain Amino Acids: what the research found →

Dose per serving from research: Branched-Chain Amino Acids

14 study groups in 2 studies say how much Branched-Chain Amino Acids participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg/kg to 25 mg/kg, 57% of 14 study groups.

Daily doseStudy groups
5 mg/kg or less
1
5 mg/kg to 10 mg/kg
1
10 mg/kg to 25 mg/kg
8
25 mg/kg to 50 mg/kg
2
50 mg/kg to 100 mg/kg
2

Dose per serving from research: Leucine

9 study groups in 3 studies say how much Leucine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 44% of 9 study groups.

Daily doseStudy groups
10 mg to 25 mg
4
25 mg to 50 mg
2
50 mg to 100 mg
0
100 mg to 250 mg
0
250 mg to 500 mg
0
500 mg to 1 g
0
1 g to 2.5 g
2
over 2.5 g
1

Commonly used together

10 of 17 study groups took Branched-Chain Amino Acids and Leucine with something else, but nothing that 3 or more different studies gave.

17 study groups

Study
The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
2020 · breakfast group · Adults aged 40 years and older admitted for rehabilitation after cerebral infarction, cerebral hemorrhage, or subarachnoid hemorrhage
125 mL1.6 g60 days23
The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
2020 · post-exercise group · Adults aged 40 years and older admitted for rehabilitation after cerebral infarction, cerebral hemorrhage, or subarachnoid hemorrhage
125 mL1.6 g60 days23
The daily valine requirement of healthy adult Indians determined by the 24-h indicator amino acid balance approach
2005 · valine intake 5 mg x kg(-1) x d(-1) · healthy, well-nourished Indian men
5 mg/kg40 mg/kg7 days—
The daily valine requirement of healthy adult Indians determined by the 24-h indicator amino acid balance approach
2005 · valine intake 10 mg x kg(-1) x d(-1) · healthy, well-nourished Indian men
10 mg/kg40 mg/kg7 days—
The daily valine requirement of healthy adult Indians determined by the 24-h indicator amino acid balance approach
2005 · valine intake 15 mg x kg(-1) x d(-1) · healthy, well-nourished Indian men
15 mg/kg40 mg/kg7 days—
The daily valine requirement of healthy adult Indians determined by the 24-h indicator amino acid balance approach
2005 · valine intake 20 mg x kg(-1) x d(-1) · healthy, well-nourished Indian men
20 mg/kg40 mg/kg7 days—
The daily valine requirement of healthy adult Indians determined by the 24-h indicator amino acid balance approach
2005 · valine intake 25 mg x kg(-1) x d(-1) · healthy, well-nourished Indian men
25 mg/kg40 mg/kg7 days—
The daily valine requirement of healthy adult Indians determined by the 24-h indicator amino acid balance approach
2005 · valine intake 30 mg x kg(-1) x d(-1) · healthy, well-nourished Indian men
30 mg/kg40 mg/kg7 days—
The daily valine requirement of healthy adult Indians determined by the 24-h indicator amino acid balance approach
2005 · valine intake 35 mg x kg(-1) x d(-1) · healthy, well-nourished Indian men
35 mg/kg40 mg/kg7 days—
Branched-chain amino acid interactions with reference to amino acid requirements in adult men: leucine metabolism at different valine and isoleucine intakes
1991 · Phase 1: leucine 40 mg/kg/day, valine 80 mg/kg/day, isoleucine 62 mg/kg/day · Healthy young adult men; six subjects were in phase 1
80 mg/kg40 mg5 days—
Branched-chain amino acid interactions with reference to amino acid requirements in adult men: leucine metabolism at different valine and isoleucine intakes
1991 · Phase 1: leucine 15 mg/kg/day, valine 80 mg/kg/day, isoleucine 62 mg/kg/day · Healthy young adult men; six subjects were in phase 1
80 mg/kg15 mg5 days—
Branched-chain amino acid interactions with reference to amino acid requirements in adult men: leucine metabolism at different valine and isoleucine intakes
1991 · Phase 1: leucine 40 mg/kg/day, valine 20 mg/kg/day, isoleucine 62 mg/kg/day · Healthy young adult men; six subjects were in phase 1
20 mg/kg—5 days—
Branched-chain amino acid interactions with reference to amino acid requirements in adult men: leucine metabolism at different valine and isoleucine intakes
1991 · Phase 1: leucine 15 mg/kg/day, valine 20 mg/kg/day, isoleucine 62 mg/kg/day · Healthy young adult men; six subjects were in phase 1
20 mg/kg15 mg5 days—
Branched-chain amino acid interactions with reference to amino acid requirements in adult men: leucine metabolism at different valine and isoleucine intakes
1991 · Phase 2: leucine 15 mg/kg/day, valine 20 mg/kg/day, isoleucine 62 mg/kg/day · Healthy young adult men; five subjects were in phase 2
20 mg/kg15 mg5 days—
Branched-chain amino acid interactions with reference to amino acid requirements in adult men: leucine metabolism at different valine and isoleucine intakes
1991 · Phase 2: leucine 40 mg/kg/day, valine 20 mg/kg/day, isoleucine 20 mg/kg/day · Healthy young adult men; five subjects were in phase 2
20 mg/kg40 mg5 days—
Branched-chain amino acid interactions with reference to amino acid requirements in adult men: leucine metabolism at different valine and isoleucine intakes
1991 · Phase 2: leucine 15 mg/kg/day, valine 20 mg/kg/day, isoleucine 20 mg/kg/day · Healthy young adult men; five subjects were in phase 2
20 mg/kg15 mg5 days—
Dileucine-supplemented essential amino acids support whole-body anabolism after resistance exercise and serum-stimulated cell-based anabolism
2025 · Branched-chain amino acid (BCAA) supplement · Healthy recreationally active adults, 27.0 ± 4.7 years old; 8 men and 4 women
1.5 g3.1 g1 day12
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