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Arginine and Vitamin C: study protocols

9 study groups took Arginine together with Vitamin C. These are the doses the studies gave. They are not a recommendation.

Arginine: what the research found →

Dose per serving from research: Arginine

9 study groups in 8 studies say how much Arginine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 g to 5 g, 44% of 9 study groups.

Daily doseStudy groups
1 g to 2.5 g
2
2.5 g to 5 g
4
5 g to 10 g
1
10 g to 25 g
2

Dose per serving from research: Vitamin C

9 study groups in 8 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg and 500 mg to 1 g, 44% of 9 study groups each.

Daily doseStudy groups
250 mg to 500 mg
4
500 mg to 1 g
4
1 g to 2.5 g
1

Commonly used together

6 of 9 study groups took Arginine and Vitamin C with something else, but nothing that 3 or more different studies gave.

9 study groups

Study
Impact of L-arginine and liposomal vitamin C supplementation on quality of life and daily life activities in patients with COPD: a randomized, multicenter, single blind, placebo-controlled trial (ILDA study)
2025 · L-arginine group · Patients with stable COPD; age and sex not specified
3.32 g1 g4 weeks76
Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial
2022 · l-arginine plus vitamin C · Men and women aged 20–60 with long COVID and persistent fatigue
3.32 g1 g4 weeks25
Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males
2017 · PWS · Apparently healthy, resistance-trained males; mean age about 21 years
2 g500 mg8 weeks27
Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males
2017 · PWS + S · Apparently healthy, resistance-trained males; mean age about 22 years
2 g500 mg8 weeks26
Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins
1999 · Methionine load with antioxidant vitamins · Healthy adults aged 25 to 45 years; 10 men and 10 women
3 g1 g1 day20
Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial
2005 · Standard diet plus two high-protein/energy supplements containing additional arginine, vitamin C and zinc · Inpatients aged 37–92 years with stage 2, 3 or 4 pressure ulcers
9 g500 mg3 weeks—
Supplemental Protein and a Multinutrient Beverage Speed Wound Healing after Acute Sleep Restriction in Healthy Adults
2022 · NUT · Generally healthy young adults aged 18–approximately 20 years (18 males and 2 females), after acute sleep restriction
20 g400 mg7 days—
Effects of l-Arginine Plus Vitamin C Supplementation on l-Arginine Metabolism in Adults with Long COVID: Secondary Analysis of a Randomized Clinical Trial
2023 · l-arginine plus vitamin C · Men and women aged 20–60 with long COVID and persistent fatigue after confirmed SARS-CoV-2 infection
3.32 g1 g4 weeks23
Multinutrient Supplementation Increases Collagen Synthesis during Early Wound Repair in a Randomized Controlled Trial in Patients with Inguinal Hernia
2020 · multinutrient group · Men scheduled for Lichtenstein inguinal hernia repair; mean age 55.2 years, with inguinal hernia disease
14 g1.25 g4 weeks10
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