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Arginine and Citrulline: study protocols

10 study groups took Arginine together with Citrulline. These are the doses the studies gave. They are not a recommendation.

Arginine: what the research found →

Dose per serving from research: Arginine

5 study groups in 3 studies say how much Arginine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mg/kg to 250 mg/kg, 60% of 5 study groups.

Daily doseStudy groups
25 mg/kg to 50 mg/kg
2
50 mg/kg to 100 mg/kg
0
100 mg/kg to 250 mg/kg
3

Dose per serving from research: Citrulline

5 study groups in 3 studies say how much Citrulline participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg/kg to 100 mg/kg, 60% of 5 study groups.

Daily doseStudy groups
25 mg/kg to 50 mg/kg
2
50 mg/kg to 100 mg/kg
3

Commonly used together

4 of 10 study groups took Arginine and Citrulline with something else, but nothing that 3 or more different studies gave.

10 study groups

Study
Asymmetric dimethylarginine predicts perioperative cardiovascular complications in patients undergoing medium-to-high risk non-cardiac surgery
2020 · L-arginine/L-citrulline group · Adults aged 30–75 years with ASA score II–IV scheduled for medium-to-high-risk non-cardiac surgery
666 mg334 mg5 days142
Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity
2016 · Watermelon (WM) condition · 20 male trained cyclists with competitive road-racing and time-trial experience
465 mg1.47 g2 weeks20
A combination of oral L-citrulline and L-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial
2019 · Cit + Arg · Male collegiate soccer players aged 18–25 years
1.2 g1.2 g7 days20
Daily 100% watermelon juice consumption and vascular function among postmenopausal women: A randomized controlled trial
2021 · 100% watermelon juice · Postmenopausal women aged 55–70 years with BMI <30 kg/m² and no stated cardiovascular disease
1.15 g1.63 g4 weeks—
Acute effects of combined supplementation of L-arginine and citrulline malate on aerobic, anaerobic, and CrossFit exercise performance
2025 · CrossFit–Cindy supplement condition · Healthy, physically active men in the CrossFit group; mean age 24.8 years
150 mg/kg100 mg/kg1 day16
Acute effects of combined supplementation of L-arginine and citrulline malate on aerobic, anaerobic, and CrossFit exercise performance
2025 · Wingate Anaerobic Test supplement condition · Healthy, physically active men in the Wingate group; mean age 28.9 years
150 mg/kg100 mg/kg1 day16
Acute effects of combined supplementation of L-arginine and citrulline malate on aerobic, anaerobic, and CrossFit exercise performance
2025 · Harvard Step Test supplement condition · Healthy, physically active men in the Harvard Step Test group; mean age 22.2 years
150 mg/kg100 mg/kg1 day14
Prevention of perceptual-motor decline by branched-chain amino acids, arginine, citrulline after tennis match
2017 · AA trial · Nine male tennis players
50 mg/kg50 mg/kg1 day9
Effects of watermelon supplementation on aortic blood pressure and wave reflection in individuals with prehypertension: a pilot study
2011 · watermelon supplementation · Adults aged 54 ± 3 years with prehypertension; four men and five women
1.3 g2.7 g6 weeks9
Branched-chain amino acids, arginine, citrulline alleviate central fatigue after 3 simulated matches in taekwondo athletes: a randomized controlled trial
2016 · AA trial · Male taekwondo athletes, age 20.0 ± 0.8 years, competing at national or international level
50 mg/kg50 mg/kg1 day12
Arginine and Citrulline: study protocols | supp.fit