Zinc, Vitamin E, Vitamin C, Copper and Vitamin A: study protocols
10 study groups took Zinc together with Vitamin E, Vitamin C, Copper and Vitamin A. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Zinc
10 study groups in 9 studies say how much Zinc participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 50% of 10 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 5 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 3 |
Dose per serving from research: Vitamin E
9 study groups in 8 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg and 10 mg to 25 mg, 44% of 9 study groups each.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 4 |
| 10 mg to 25 mg | 4 |
Dose per serving from research: Vitamin C
9 study groups in 8 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 44% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg to 50 mg | 4 |
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 2 |
Dose per serving from research: Copper
10 study groups in 9 studies say how much Copper participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mcg to 1 mg, 50% of 10 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mcg to 500 mcg | 2 |
| 500 mcg to 1 mg | 5 |
| 1 mg to 2.5 mg | 1 |
| 2.5 mg to 5 mg | 2 |
Dose per serving from research: Vitamin A
7 study groups in 6 studies say how much Vitamin A participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mcg to 1 mg, 43% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 1 |
| 250 mcg to 500 mcg | 1 |
| 500 mcg to 1 mg | 3 |
| 1 mg to 2.5 mg | 2 |
Commonly used together
10 of 10 study groups took Zinc, Vitamin E, Vitamin C, Copper and Vitamin A with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Iron | 10 |
| Iodine | 8 |
| Vitamin D | 8 |
| Selenium | 7 |
| Vitamin B12 | 7 |
| Folic Acid | 6 |
| Niacin | 6 |
| Vitamin B6 | 6 |
| Vitamin K | 4 |
| vitamin B1 | 4 |
10 study groups
| Study | |||||||
|---|---|---|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 30 mg | 10 mg | 100 mg | 2 mg | 1 mg | — | — |
| Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa 2009 · multiple micronutrients · children aged 6–24 months; three cohorts: HIV-infected children, HIV-uninfected children born to HIV-infected mothers, and HIV-uninfected children born to HIV-uninfected mothers | 10 mg | 6 mg | 35 mg | 600 mcg | 1,250 IU | 548 days | — |
| Effect of preventive supplementation with zinc and other micronutrients on non-malarial morbidity in Tanzanian pre-school children: a randomized trial 2012 · Multi-nutrients with zinc · Children aged 6–60 months with height-for-age z-score ≤−1.5 SD, in rural Tanzania | 10 mg | — | — | 340 mcg | — | — | 151 |
| Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial 2010 · Micronutrient-fortified milk (MN group) · Children aged 1–4 years in India; many had anemia, iron deficiency, or growth faltering | 7.8 mg | 7.5 mg | 40.2 mg | 270 mcg | 156 mcg | 1 year | 316 |
| Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months 2010 · Multiple micronutrients · Children enrolled at 6 months and followed to 24 months in rural South Africa; HIV-infected and HIV-uninfected children, both sexes | 10 mg | 6 mg | 35 mg | 600 mcg | 1,250 IU | 548 days | 126 |
| Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh 2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh | 12 mg | 15 mg | 85 mg | 1 mg | 770 mcg | 165 days | 749 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 12 mg | 15 mg | 85 mg | 1 mg | 770 mcg | — | 176 |
| mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status 2017 · MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia | 30 mg | 20 mg | 140 mg | 4 mg | 1.6 mg | 184 days | 75 |
| mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status 2017 · PE+MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia | 30 mg | 20 mg | 140 mg | 4 mg | 1.6 mg | 184 days | 75 |
| Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial 2021 · intervention · Children aged 6–9 years, apparently healthy, in rural Hai Phong City, Vietnam; included undernourished, normal-weight, and overweight/obese children | 10 mg | 5 mg | 30 mg | 560 mcg | 400 mcg | 22 weeks | 175 |