| Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial 2025 · active placebo group · Children aged 3–18 years with a documented history of recurrent respiratory tract infections | 5 mg | 10 mcg | 90 days | 113 |
| Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial 2025 · active group · Children aged 3–18 years with a documented history of recurrent respiratory tract infections | 5 mg | 10 mcg | 90 days | 104 |
| Effect of an Immune-Boosting, Antioxidant and Anti-Inflammatory Food Supplement in Hospitalized COVID-19 Patients: A Prospective Randomized Pilot Study 2023 · intervention group · Adults aged 18 years or older hospitalized with PCR-confirmed COVID-19 who required more than 48 hours of admission | 1.5 mg | 0.75 mcg | — | 78 |
| Difensil Immuno Reduces Recurrence and Severity of Tonsillitis in Children: A Randomized Controlled Trial 2020 · Group B (GB) · Children younger than 8 years with at least 3 fever-associated tonsillitis episodes per year and Mackenzie score >2 | 11.2 mg | 15 mcg | 45 days | 41 |
| Difensil Immuno Reduces Recurrence and Severity of Tonsillitis in Children: A Randomized Controlled Trial 2020 · Group A (GA) · Children younger than 8 years with at least 3 fever-associated tonsillitis episodes per year and Mackenzie score >2 | 7.5 mg | 10 mcg | 90 days | 40 |
| Effects of multimicronutrient supplementation on helminth reinfection: a randomized, controlled trial in Kenyan schoolchildren 2003 · multimicronutrient supplementation · Schoolchildren in Nyanza Province, Kenya; age and sex not specified | 20 mg | 5 mcg | 335 days | — |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 30 mg | 10 mcg | — | — |
| Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa 2009 · multiple micronutrients · children aged 6–24 months; three cohorts: HIV-infected children, HIV-uninfected children born to HIV-infected mothers, and HIV-uninfected children born to HIV-uninfected mothers | 10 mg | 5 mcg | 548 days | — |
| Effect of preventive supplementation with zinc and other micronutrients on non-malarial morbidity in Tanzanian pre-school children: a randomized trial 2012 · Multi-nutrients with zinc · Children aged 6–60 months with height-for-age z-score ≤−1.5 SD, in rural Tanzania | 10 mg | — | — | 151 |
| Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial 2020 · Vitamin D plus zinc group · Overweight or obese adults with depressive symptoms and BDI-II score ≥10; mean age 38.35 years | 30 mg | 2,000 IU | 12 weeks | — |
| Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months 2010 · Multiple micronutrients · Children enrolled at 6 months and followed to 24 months in rural South Africa; HIV-infected and HIV-uninfected children, both sexes | 10 mg | 5 mcg | 548 days | 126 |
| Melatonin, vitamins and minerals supplements for the treatment of Covid-19 and Covid-like illness: A prospective, randomized, double-blind multicenter study 2024 · Treatment group · Adults younger than 60 years with COVID-19 or COVID-like illness, no previous medical history, and not hospitalized | 25 mg | 2.5 mcg | — | 82 |
| Effect of zinc plus multivitamin supplementation on growth in school children 2016 · Chelated zinc plus multivitamins · Healthy Thai schoolchildren aged 4–13 years | 20 mg | 200 IU | 26 weeks | 70 |
| Effects of Low-Dose Dairy Protein Plus Micronutrient Supplementation during Resistance Exercise on Muscle Mass and Physical Performance in Older Adults: A Randomized, Controlled Trial 2018 · ExPM (resistance exercise plus low-dose dairy protein and micronutrient supplementation) · Adults aged 65–80 years, non-disabled and not exercising regularly | 8 mg | 5 mcg | 12 weeks | 40 |
| Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial 2018 · Magnesium-zinc-calcium-vitamin D co-supplementation · Women with polycystic ovary syndrome (PCOS); age not reported | 8 mg | 400 IU | 12 weeks | 30 |
| The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older Adults: A Double-Blind, Randomized, Controlled Trial 2020 · Redoxon® Vita Immune (MVM) · Healthy men and women aged 55–75 years | 10 mg | — | 12 weeks | 21 |
| Effects of Macuprev(®) Supplementation in Age-Related Macular Degeneration: A Double-Blind Randomized Morpho-Functional Study Along 6 Months of Follow-Up 2019 · AMD-M group · Adults with intermediate age-related macular degeneration; 9 male and 21 female enrolled overall, mean age 69.32 years | 16 mg | 800 IU | 26 weeks | 15 |
| School-based calcium-vitamin D with micronutrient supplementation enhances bone mass in underprivileged Indian premenarchal girls 2012 · Ca+MZ-group · Premenarchal girls aged 8–12 years from low-income groups in Pune, India | 15 mg | — | 1 year | — |
| Effect of micronutrient supplementation on height velocity of underprivileged girls in comparison with un-supplemented healthy controls 2014 · Ca+MZn+D group (C1) · Underprivileged premenarchal girls aged 8–12 years | 15 mg | — | 1 year | — |
| [Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter trial] 2004 · Group 1: Vitrum Osteomag · Postmenopausal women with osteopenia; age range not reported | 15 mg | 400 IU | 1 year | 125 |
| Calcium and vitamin D fortified milk reduces bone turnover and improves bone density in postmenopausal women over 1 year 2018 · intervention · Chinese postmenopausal women in Malaysia; mean age 59 years | 2.4 mg | 15 mcg | 1 year | 61 |
| Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial 2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception | 10 mg | 10 mcg | — | 870 |
| Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh 2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh | 12 mg | 5 mcg | 165 days | 749 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 12 mg | 5 mcg | — | 176 |
| mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status 2017 · MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia | 30 mg | 400 IU | 184 days | 75 |
| mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status 2017 · PE+MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia | 30 mg | 400 IU | 184 days | 75 |
| Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient sprinkles on fatty acid status in Cambodian infants 2007 · mineral/micronutrient (MMN) · Cambodian infants aged 6 months at enrolment | 5 mg | — | 1 year | 68 |
| Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut 2021 · MNP with zinc · Children enrolled at 6 months of age in Pakistan; included undernourished and reference weight-for-length groups | 10 mg | — | 1 year | 889 |
| A Trial on The Effects of Magnesium-Zinc-Calcium-Vitamin D Co-Supplementation on Glycemic Control and Markers of Cardio-Metabolic Risk in Women with Polycystic Ovary Syndrome 2017 · Magnesium-zinc-calcium-vitamin D co-supplementation · Women with polycystic ovary syndrome (PCOS) | 8 mg | 400 IU | 12 weeks | 30 |
| The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes 2019 · Magnesium-zinc-calcium-vitamin D group · Women aged 18–40 with gestational diabetes mellitus, at 24–28 weeks’ gestation at diagnosis | 8 mg | 400 IU | 6 weeks | 30 |
| Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women 2016 · Intervention (Int), premenopausal women · Premenopausal women, mean age 41 years; no specific condition stated | 2.4 mg | 15 mcg | 12 weeks | — |
| Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women 2016 · Intervention (Int), postmenopausal women · Postmenopausal women, mean age 59 years; no specific condition stated | 2.4 mg | 15 mcg | 12 weeks | — |
