Zinc, Vitamin C, Vitamin E and Beta-Carotene: study protocols
15 study groups took Zinc together with Vitamin C, Vitamin E and Beta-Carotene. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Zinc
15 study groups in 13 studies say how much Zinc participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 53% of 15 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mg to 25 mg | 8 |
| 25 mg to 50 mg | 0 |
| 50 mg to 100 mg | 7 |
Dose per serving from research: Vitamin C
15 study groups in 13 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 53% of 15 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg to 250 mg | 7 |
| 250 mg to 500 mg | 8 |
Dose per serving from research: Vitamin E
8 study groups in 6 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 IU to 500 IU, 100% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 250 IU to 500 IU | 8 |
Dose per serving from research: Beta-Carotene
15 study groups in 13 studies say how much Beta-Carotene participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 53% of 15 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 7 |
| 10 mg to 25 mg | 8 |
Commonly used together
15 of 15 study groups took Zinc, Vitamin C, Vitamin E and Beta-Carotene with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Selenium | 7 |
| Copper | 5 |
15 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Response to AREDS supplements according to genetic factors: survival analysis approach using the eye as the unit of analysis 2016 · combination of antioxidants and zinc · Adults aged 55 years and older with age-related macular degeneration; eyes with advanced disease at baseline and participants with no AMD in both eyes were excluded | 80 mg | 500 mg | 400 IU | 15 mg | 2409 days | — |
| A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8 2001 · Antioxidants plus zinc · Adults aged 55–80 with age-related macular degeneration Categories 2–4 and visual acuity of 20/32 or better in at least one eye | 80 mg | 500 mg | 400 IU | 15 mg | 8 years | — |
| Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13 2004 · antioxidants plus zinc · Adults aged 55–81 years with AMD categories 2–4 and AREDS ocular eligibility | 80 mg | 500 mg | 400 IU | 15 mg | 339 weeks | — |
| The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals 2004 · antioxidant supplement group · French women aged 35–60 and men aged 45–60 in the general population | 20 mg | 120 mg | 30 mg | 6 mg | 2739 days | — |
| Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels? 2005 · daily antioxidant supplementation · French adults: women aged 35–60 years and men aged 45–60 years | 20 mg | 120 mg | 30 mg | 6 mg | 2739 days | — |
| Antioxidant supplementation increases the risk of skin cancers in women but not in men 2007 · antioxidant group · French adult women and men in a general-population primary-prevention trial | 20 mg | 120 mg | 30 mg | 6 mg | 2738 days | — |
| Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35 2013 · Antioxidants plus zinc · Adults aged 55–80 with age-related macular degeneration (AREDS categories 1–4) | 80 mg | 500 mg | 400 IU | 15 mg | 339 weeks | — |
| Effect of two years' supplementation with natural antioxidants on vitamin and trace element status biomarkers: preliminary data of the SU.VI.MAX study 2001 · Antioxidant supplementation group · Women aged 35–60 years and men aged 45–60 years in France, general population | 20 mg | 120 mg | 30 mg | 6 mg | 2 years | — |
| Effect of 6 month supplementation with different combinations of an association of antioxidant nutrients on biochemical parameters and markers of the antioxidant defence system in the elderly. The Geriatrie/Min.Vit.Aox Network 1996 · VT (vitamins associated with trace elements) · Elderly nursing-home residents aged 65–103 years who were long-term hospitalized | 20 mg | 120 mg | 15 mg | 6 mg | 26 weeks | — |
| Effects of trace element and/or vitamin supplementation on vitamin and mineral status, free radical metabolism and immunological markers in elderly long term-hospitalized subjects. Geriatric Network MIN. VIT. AOX 1997 · trace elements associated with vitamins · Institutionalized elderly subjects in long-term hospital or nursing-home care | 20 mg | 120 mg | 15 mg | 6 mg | 1 year | — |