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Zinc, Vitamin C, Selenium and Vitamin E: study protocols

14 study groups took Zinc together with Vitamin C, Selenium and Vitamin E. These are the doses the studies gave. They are not a recommendation.

Zinc: what the research found →

Dose per serving from research: Zinc

14 study groups in 13 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 64% of 14 study groups.

Daily doseStudy groups
5 mg to 10 mg
3
10 mg to 25 mg
9
25 mg to 50 mg
2

Dose per serving from research: Vitamin C

13 study groups in 12 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mg to 250 mg, 69% of 13 study groups.

Daily doseStudy groups
25 mg to 50 mg
2
50 mg to 100 mg
2
100 mg to 250 mg
9

Dose per serving from research: Selenium

12 study groups in 11 studies say how much Selenium participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mcg to 100 mcg, 58% of 12 study groups.

Daily doseStudy groups
10 mcg or less
1
10 mcg to 25 mcg
2
25 mcg to 50 mcg
0
50 mcg to 100 mcg
7
100 mcg to 250 mcg
2

Dose per serving from research: Vitamin E

13 study groups in 12 studies say how much Vitamin E participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 46% of 13 study groups.

Daily doseStudy groups
5 mg or less
1
5 mg to 10 mg
1
10 mg to 25 mg
6
25 mg to 50 mg
5

Commonly used together

14 of 14 study groups took Zinc, Vitamin C, Selenium and Vitamin E with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Beta-Carotene
7
Copper
7
Iron
7
Vitamin A
7
Iodine
6
Folic Acid
5
Vitamin D
5
Vitamin B12
4
Vitamin B6
3

14 study groups

Study
The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals
2004 · antioxidant supplement group · French women aged 35–60 and men aged 45–60 in the general population
20 mg120 mg100 mcg30 mg2739 days—
Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
2005 · daily antioxidant supplementation · French adults: women aged 35–60 years and men aged 45–60 years
20 mg120 mg100 mcg30 mg2739 days—
Antioxidant supplementation increases the risk of skin cancers in women but not in men
2007 · antioxidant group · French adult women and men in a general-population primary-prevention trial
20 mg120 mg—30 mg2738 days—
Effect of preventive supplementation with zinc and other micronutrients on non-malarial morbidity in Tanzanian pre-school children: a randomized trial
2012 · Multi-nutrients with zinc · Children aged 6–60 months with height-for-age z-score ≤−1.5 SD, in rural Tanzania
10 mg—20 mcg——151
Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial
2010 · Micronutrient-fortified milk (MN group) · Children aged 1–4 years in India; many had anemia, iron deficiency, or growth faltering
7.8 mg40.2 mg4.2 mcg7.5 mg1 year316
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
12 mg85 mg60 mcg15 mg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
12 mg85 mg60 mcg15 mg—176
mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status
2017 · MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia
30 mg140 mg130 mcg20 mg184 days75
mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status
2017 · PE+MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia
30 mg140 mg130 mcg20 mg184 days75
Effect of two years' supplementation with natural antioxidants on vitamin and trace element status biomarkers: preliminary data of the SU.VI.MAX study
2001 · Antioxidant supplementation group · Women aged 35–60 years and men aged 45–60 years in France, general population
20 mg120 mg100 mcg30 mg2 years—