Zinc, Vitamin A, Vitamin C and Iron: study protocols
16 study groups took Zinc together with Vitamin A, Vitamin C and Iron. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Zinc
16 study groups in 14 studies say how much Zinc participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 38% of 16 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mg or less | 1 |
| 2.5 mg to 5 mg | 4 |
| 5 mg to 10 mg | 6 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 3 |
Dose per serving from research: Vitamin A
12 study groups in 10 studies say how much Vitamin A participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 42% of 12 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 2 |
| 250 mcg to 500 mcg | 5 |
| 500 mcg to 1 mg | 3 |
| 1 mg to 2.5 mg | 2 |
Dose per serving from research: Vitamin C
14 study groups in 12 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 50% of 14 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mg or less | 1 |
| 10 mg to 25 mg | 1 |
| 25 mg to 50 mg | 7 |
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 2 |
Dose per serving from research: Iron
13 study groups in 11 studies say how much Iron participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 38% of 13 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 5 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 3 |
| 50 mg to 100 mg | 2 |
Commonly used together
13 of 16 study groups took Zinc, Vitamin A, Vitamin C and Iron with something else. Shown: what 3 or more different studies gave. The 10 most common of 13.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Copper | 10 |
| Vitamin E | 10 |
| Folic Acid | 9 |
| Vitamin D | 9 |
| Iodine | 8 |
| Selenium | 7 |
| Vitamin B12 | 7 |
| Niacin | 6 |
| Vitamin B6 | 6 |
| Vitamin K | 4 |
16 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Impact of iron fortification on anaemia and iron deficiency among pre-school children living in Rural Ghana 2021 · iron-MNP group · Children aged 6–35 months living in rural Ghana; children with severe anaemia, severe malnutrition, recent iron supplementation, or chronic disease were excluded. | 5 mg | 400 mcg | 30 mg | 12.5 mg | 150 days | 967 |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 30 mg | 1 mg | 100 mg | — | — | — |
| Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa 2009 · multiple micronutrients · children aged 6–24 months; three cohorts: HIV-infected children, HIV-uninfected children born to HIV-infected mothers, and HIV-uninfected children born to HIV-uninfected mothers | 10 mg | 1,250 IU | 35 mg | 10 mg | 548 days | — |
| Effect of preventive supplementation with zinc and other micronutrients on non-malarial morbidity in Tanzanian pre-school children: a randomized trial 2012 · Multi-nutrients with zinc · Children aged 6–60 months with height-for-age z-score ≤−1.5 SD, in rural Tanzania | 10 mg | — | — | — | — | 151 |
| Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial 2010 · Micronutrient-fortified milk (MN group) · Children aged 1–4 years in India; many had anemia, iron deficiency, or growth faltering | 7.8 mg | 156 mcg | 40.2 mg | 9.6 mg | 1 year | 316 |
| Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months 2010 · Multiple micronutrients · Children enrolled at 6 months and followed to 24 months in rural South Africa; HIV-infected and HIV-uninfected children, both sexes | 10 mg | 1,250 IU | 35 mg | 10 mg | 548 days | 126 |
| Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh 2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh | 12 mg | 770 mcg | 85 mg | 27 mg | 165 days | 749 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 12 mg | 770 mcg | 85 mg | 27 mg | — | 176 |
| mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status 2017 · MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia | 30 mg | 1.6 mg | 140 mg | 60 mg | 184 days | 75 |
| mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status 2017 · PE+MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia | 30 mg | 1.6 mg | 140 mg | 60 mg | 184 days | 75 |