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Zinc, Iron, Folic Acid and Vitamin B12: study protocols

6 study groups took Zinc together with Iron, Folic Acid and Vitamin B12. These are the doses the studies gave. They are not a recommendation.

Zinc: what the research found →

Dose per serving from research: Zinc

6 study groups in 6 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mg to 10 mg and 10 mg to 25 mg, 33% of 6 study groups each.

Daily doseStudy groups
5 mg or less
1
5 mg to 10 mg
2
10 mg to 25 mg
2
25 mg to 50 mg
1

Dose per serving from research: Iron

5 study groups in 5 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mg to 10 mg and 25 mg to 50 mg, 40% of 5 study groups each.

Daily doseStudy groups
5 mg to 10 mg
2
10 mg to 25 mg
1
25 mg to 50 mg
2

Dose per serving from research: Folic Acid

6 study groups in 6 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mcg to 250 mcg and 250 mcg to 500 mcg and 500 mcg to 1 mg, 33% of 6 study groups each.

Daily doseStudy groups
100 mcg to 250 mcg
2
250 mcg to 500 mcg
2
500 mcg to 1 mg
2

Dose per serving from research: Vitamin B12

6 study groups in 6 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 50% of 6 study groups.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
3
over 5 mcg
1

Commonly used together

6 of 6 study groups took Zinc, Iron, Folic Acid and Vitamin B12 with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin A
5
Copper
4
Iodine
4
Vitamin B6
4
Vitamin C
4
Vitamin D
4
Vitamin E
4
Selenium
3

6 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
30 mg—400 mcg2.6 mcg——
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
10 mg12 mg400 mcg5.2 mcg—870
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
12 mg27 mg600 mcg2.6 mcg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
12 mg27 mg600 mcg2.6 mcg—176
Community-level micronutrient fortification of school lunch meals improved vitamin A, folate, and iron status of schoolchildren in Himalayan villages of India
2010 · multiple micronutrients (treatment group) · Schoolchildren aged 6–10 years in Himalayan villages of India
4.2 mg10 mg225 mcg1.35 mcg240 days—
Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial
2021 · intervention · Children aged 6–9 years, apparently healthy, in rural Hai Phong City, Vietnam; included undernourished, normal-weight, and overweight/obese children
10 mg10 mg150 mcg0.9 mcg22 weeks175