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Zinc, Iron, Folic Acid and Vitamin A: study protocols

13 study groups took Zinc together with Iron, Folic Acid and Vitamin A. These are the doses the studies gave. They are not a recommendation.

Zinc: what the research found →

Dose per serving from research: Zinc

13 study groups in 10 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 46% of 13 study groups.

Daily doseStudy groups
2.5 mg to 5 mg
3
5 mg to 10 mg
2
10 mg to 25 mg
2
25 mg to 50 mg
6

Dose per serving from research: Iron

11 study groups in 9 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 50 mg to 100 mg, 45% of 11 study groups.

Daily doseStudy groups
5 mg to 10 mg
2
10 mg to 25 mg
1
25 mg to 50 mg
3
50 mg to 100 mg
5

Dose per serving from research: Folic Acid

12 study groups in 9 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 50% of 12 study groups.

Daily doseStudy groups
100 mcg to 250 mcg
4
250 mcg to 500 mcg
6
500 mcg to 1 mg
2

Dose per serving from research: Vitamin A

12 study groups in 9 studies say how much Vitamin A participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 50% of 12 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
4
500 mcg to 1 mg
6
1 mg to 2.5 mg
2

Commonly used together

11 of 13 study groups took Zinc, Iron, Folic Acid and Vitamin A with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin C
9
Copper
6
Vitamin D
6
Vitamin E
6
Iodine
5
Selenium
5
Vitamin B12
5
Vitamin B6
3

13 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Folic acid + iron + zinc · Pregnant women in rural Nepal
30 mg60 mg400 mcg1 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
30 mg—400 mcg1 mg——
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
12 mg27 mg600 mcg770 mcg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
12 mg27 mg600 mcg770 mcg—176
mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status
2017 · MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia
30 mg60 mg400 mcg1.6 mg184 days75
mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status
2017 · PE+MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia
30 mg60 mg400 mcg1.6 mg184 days75
Short-term daily or weekly administration of micronutrient Sprinkles has high compliance and does not cause iron overload in Chinese schoolchildren: a cluster-randomised trial
2006 · daily group · Children aged 3–6 years in a kindergarten in northern China
5 mg30 mg150 mcg300 mcg13 weeks—
Community-level micronutrient fortification of school lunch meals improved vitamin A, folate, and iron status of schoolchildren in Himalayan villages of India
2010 · multiple micronutrients (treatment group) · Schoolchildren aged 6–10 years in Himalayan villages of India
4.2 mg10 mg225 mcg375 mcg240 days—
Micronutrient supplements can promote disruptive protozoan and fungal communities in the developing infant gut
2021 · MNP with zinc · Children enrolled at 6 months of age in Pakistan; included undernourished and reference weight-for-length groups
10 mg———1 year889
Micronutrient Sprinkles reduce anemia among 9- to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti
2007 · Sprinkles-WSB (S-WSB) · Children aged 9–24 months in rural Haiti receiving take-home fortified wheat-soy blend rations
5 mg12.5 mg160 mcg400 mcg60 days254