Zinc, Copper, Vitamin E and Vitamin C: study protocols
17 study groups took Zinc together with Copper, Vitamin E and Vitamin C. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Zinc
17 study groups in 12 studies say how much Zinc participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg and 50 mg to 100 mg, 29% of 17 study groups each.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 5 |
| 10 mg to 25 mg | 4 |
| 25 mg to 50 mg | 3 |
| 50 mg to 100 mg | 5 |
Dose per serving from research: Copper
14 study groups in 12 studies say how much Copper participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mcg to 1 mg and 1 mg to 2.5 mg, 36% of 14 study groups each.
| Daily dose | Study groups |
|---|---|
| 250 mcg to 500 mcg | 2 |
| 500 mcg to 1 mg | 5 |
| 1 mg to 2.5 mg | 5 |
| 2.5 mg to 5 mg | 2 |
Dose per serving from research: Vitamin E
9 study groups in 8 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg and 10 mg to 25 mg, 44% of 9 study groups each.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 4 |
| 10 mg to 25 mg | 4 |
Dose per serving from research: Vitamin C
16 study groups in 11 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 44% of 16 study groups.
| Daily dose | Study groups |
|---|---|
| 25 mg to 50 mg | 4 |
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 2 |
| 250 mg to 500 mg | 7 |
Commonly used together
15 of 17 study groups took Zinc, Copper, Vitamin E and Vitamin C with something else. Shown: what 3 or more different studies gave. The 10 most common of 14.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Iron | 10 |
| Vitamin A | 10 |
| Iodine | 8 |
| Vitamin D | 8 |
| Selenium | 7 |
| Vitamin B12 | 7 |
| Folic Acid | 6 |
| Niacin | 6 |
| Vitamin B6 | 6 |
| Beta-Carotene | 5 |
17 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Response to AREDS supplements according to genetic factors: survival analysis approach using the eye as the unit of analysis 2016 · combination of antioxidants and zinc · Adults aged 55 years and older with age-related macular degeneration; eyes with advanced disease at baseline and participants with no AMD in both eyes were excluded | 80 mg | 2 mg | 400 IU | 500 mg | 2409 days | — |
| A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8 2001 · Antioxidants plus zinc · Adults aged 55–80 with age-related macular degeneration Categories 2–4 and visual acuity of 20/32 or better in at least one eye | 80 mg | 2 mg | 400 IU | 500 mg | 8 years | — |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 30 mg | 2 mg | 10 mg | 100 mg | — | — |
| Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa 2009 · multiple micronutrients · children aged 6–24 months; three cohorts: HIV-infected children, HIV-uninfected children born to HIV-infected mothers, and HIV-uninfected children born to HIV-uninfected mothers | 10 mg | 600 mcg | 6 mg | 35 mg | 548 days | — |
| Effect of preventive supplementation with zinc and other micronutrients on non-malarial morbidity in Tanzanian pre-school children: a randomized trial 2012 · Multi-nutrients with zinc · Children aged 6–60 months with height-for-age z-score ≤−1.5 SD, in rural Tanzania | 10 mg | 340 mcg | — | — | — | 151 |
| Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial 2010 · Micronutrient-fortified milk (MN group) · Children aged 1–4 years in India; many had anemia, iron deficiency, or growth faltering | 7.8 mg | 270 mcg | 7.5 mg | 40.2 mg | 1 year | 316 |
| Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months 2010 · Multiple micronutrients · Children enrolled at 6 months and followed to 24 months in rural South Africa; HIV-infected and HIV-uninfected children, both sexes | 10 mg | 600 mcg | 6 mg | 35 mg | 548 days | 126 |
| Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh 2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh | 12 mg | 1 mg | 15 mg | 85 mg | 165 days | 749 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 12 mg | 1 mg | 15 mg | 85 mg | — | 176 |
| mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status 2017 · MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia | 30 mg | 4 mg | 20 mg | 140 mg | 184 days | 75 |