Zeaxanthin, Lutein, Docosahexaenoic Acid and Omega-3 Fatty Acids: study protocols
5 study groups took Zeaxanthin together with Lutein, Docosahexaenoic Acid and Omega-3 Fatty Acids. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Zeaxanthin
5 study groups in 4 studies say how much Zeaxanthin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 80% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mg or less | 1 |
| 1 mg to 2.5 mg | 4 |
Dose per serving from research: Lutein
5 study groups in 4 studies say how much Lutein participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 100% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 5 |
Dose per serving from research: Docosahexaenoic Acid
5 study groups in 4 studies say how much Docosahexaenoic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 80% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mg or less | 1 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 4 |
Dose per serving from research: Omega-3 Fatty Acids
5 study groups in 4 studies say how much Omega-3 Fatty Acids participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 mg to 100 mg and 500 mg to 1 g, 40% of 5 study groups each.
| Daily dose | Study groups |
|---|---|
| 25 mg to 50 mg | 1 |
| 50 mg to 100 mg | 2 |
| 100 mg to 250 mg | 0 |
| 250 mg to 500 mg | 0 |
| 500 mg to 1 g | 2 |
Commonly used together
2 of 5 study groups took Zeaxanthin, Lutein, Docosahexaenoic Acid and Omega-3 Fatty Acids with something else, but nothing that 3 or more different studies gave.
5 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial 2013 · lutein + zeaxanthin and DHA + EPA group · Adults aged 50 to 85 years at risk for progression to advanced age-related macular degeneration, with bilateral large drusen or large drusen in one eye and advanced AMD in the fellow eye | 2 mg | 10 mg | 350 mg | 650 mg | 5 years | — |
| Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults 2023 · LCPUFAs + LZ group, Trial 2 · Healthy Japanese adults aged 55–79 with memory complaints and no dementia; cognitive-decline subgroup had MoCA-J scores below 23 | 2 mg | 10 mg | 300 mg | 100 mg | 12 weeks | 96 |
| Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults 2023 · LCPUFAs + LZ group, Trial 1 · Healthy Japanese adults aged 55–79 with memory complaints and no dementia; cognitive-decline subgroup had MoCA-J scores below 23 | 2 mg | 10 mg | 300 mg | 100 mg | 24 weeks | 40 |
| Macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial 2013 · group 1 · Individuals with nonexudative age-related macular degeneration; age and sex not specified | 1 mg | 10 mg | 100 mg | 30 mg | 1 year | — |
| Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macular Degeneration 2025 · AREDS2 lutein/zeaxanthin plus DHA/EPA · Adults aged 50–85 with large drusen in both eyes or late AMD in one eye and large drusen in the fellow eye | 2 mg | 10 mg | 350 mg | 650 mg | 5 years | — |