Vitamin E, Folic Acid, Vitamin B6 and Vitamin B12: study protocols
5 study groups took Vitamin E together with Folic Acid, Vitamin B6 and Vitamin B12. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin E
5 study groups in 4 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 40% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 1 |
| 10 mg to 25 mg | 1 |
| 25 mg to 50 mg | 2 |
Dose per serving from research: Folic Acid
5 study groups in 4 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 60% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 1 |
| 250 mcg to 500 mcg | 3 |
| 500 mcg to 1 mg | 1 |
Dose per serving from research: Vitamin B6
5 study groups in 4 studies say how much Vitamin B6 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mcg to 1 mg and 1 mg to 2.5 mg, 40% of 5 study groups each.
| Daily dose | Study groups |
|---|---|
| 500 mcg or less | 1 |
| 500 mcg to 1 mg | 2 |
| 1 mg to 2.5 mg | 2 |
Dose per serving from research: Vitamin B12
5 study groups in 4 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 80% of 5 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mcg or less | 1 |
| 1 mcg to 2.5 mcg | 0 |
| 2.5 mcg to 5 mcg | 4 |
Commonly used together
5 of 5 study groups took Vitamin E, Folic Acid, Vitamin B6 and Vitamin B12 with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin C | 5 |
| Selenium | 4 |
| Copper | 3 |
| Iron | 3 |
| Vitamin A | 3 |
| Zinc | 3 |
5 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 10 mg | 400 mcg | 2.2 mg | 2.6 mcg | — | — |
| Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease 2015 · Active group (RCT1, RCT2 and RCT3) · Men and women aged 50 years or older with mild or mild-to-moderate Alzheimer's disease; RCT3 participants were on stable approved Alzheimer's medication, while RCT1 and RCT2 participants were drug-free for Alzheimer's medication. | 40 mg | 400 mcg | 1 mg | 3 mcg | 24 weeks | 501 |
| Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease 2015 · Active product during open-label extension (OLE) · Men and women aged 50 years or older with mild Alzheimer's disease who completed RCT2. | 40 mg | 400 mcg | 1 mg | 3 mcg | 24 weeks | 201 |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 15 mg | 600 mcg | 1.9 mg | 2.6 mcg | — | 176 |
| Multiple Micronutrient Powder Reduces Vitamin E Deficiency in Brazilian Children: A Pragmatic, Controlled Clinical Trial 2019 · intervention group · Children aged 6–9 months at the start of the study, male or female, attending primary health care centers in Goiânia, Brazil | 5 mg | 150 mcg | 500 mcg | 0.9 mcg | 90 days | 107 |