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Vitamin D, Folic Acid and Vitamin B12: study protocols

5 study groups took Vitamin D together with Folic Acid and Vitamin B12. These are the doses the studies gave. They are not a recommendation.

Vitamin D: what the research found →

Dose per serving from research: Vitamin D

5 study groups in 5 studies say how much Vitamin D participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mcg to 10 mcg, 60% of 5 study groups.

Daily doseStudy groups
2.5 mcg to 5 mcg
2
5 mcg to 10 mcg
3

Dose per serving from research: Folic Acid

5 study groups in 5 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg and 500 mcg to 1 mg, 40% of 5 study groups each.

Daily doseStudy groups
100 mcg to 250 mcg
1
250 mcg to 500 mcg
2
500 mcg to 1 mg
2

Dose per serving from research: Vitamin B12

5 study groups in 5 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 60% of 5 study groups.

Daily doseStudy groups
2.5 mcg to 5 mcg
3
5 mcg to 10 mcg
2

Commonly used together

5 of 5 study groups took Vitamin D, Folic Acid and Vitamin B12 with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Iron
4
Vitamin B6
4
Zinc
4
Copper
3
Iodine
3
Riboflavin
3
Vitamin A
3
Vitamin C
3
Vitamin E
3

5 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
10 mcg400 mcg2.6 mcg——
A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status
2022 · B-vitamin treatment · Community-dwelling adults aged 50 years or older; men and women; no specific diagnosed condition, and not currently taking B-vitamin supplements at screening
10 mcg200 mcg10 mcg2 years103
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
10 mcg400 mcg5.2 mcg—870
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
5 mcg600 mcg2.6 mcg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
5 mcg600 mcg2.6 mcg—176
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