Vitamin C, Zinc and Vitamin E: study protocols
20 study groups took Vitamin C together with Zinc and Vitamin E. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin C
20 study groups in 16 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 40% of 20 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 3 |
| 100 mg to 250 mg | 7 |
| 250 mg to 500 mg | 8 |
| 500 mg to 1 g | 0 |
| over 1 g | 1 |
Dose per serving from research: Zinc
20 study groups in 16 studies say how much Zinc participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 45% of 20 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mg to 5 mg | 2 |
| 5 mg to 10 mg | 1 |
| 10 mg to 25 mg | 9 |
| 25 mg to 50 mg | 1 |
| 50 mg to 100 mg | 7 |
Dose per serving from research: Vitamin E
11 study groups in 11 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 45% of 11 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mg to 2.5 mg | 2 |
| 2.5 mg to 5 mg | 0 |
| 5 mg to 10 mg | 2 |
| 10 mg to 25 mg | 2 |
| 25 mg to 50 mg | 5 |
Commonly used together
20 of 20 study groups took Vitamin C, Zinc and Vitamin E with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Beta-Carotene | 13 |
| Copper | 8 |
| Selenium | 8 |
| Vitamin A | 3 |
20 study groups
| Study | |||||
|---|---|---|---|---|---|
| Megadose vitamins in bladder cancer: a double-blind clinical trial 1994 · megadose vitamins arm · Patients with biopsy-confirmed transitional cell carcinoma of the bladder receiving BCG immunotherapy | 2 g | 90 mg | — | — | 35 |
| A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8 2001 · Antioxidants plus zinc · Adults aged 55–80 with age-related macular degeneration Categories 2–4 and visual acuity of 20/32 or better in at least one eye | 500 mg | 80 mg | 400 IU | 8 years | — |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 100 mg | 30 mg | 10 mg | — | — |
| Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13 2004 · antioxidants plus zinc · Adults aged 55–81 years with AMD categories 2–4 and AREDS ocular eligibility | 500 mg | 80 mg | 400 IU | 339 weeks | — |
| The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals 2004 · antioxidant supplement group · French women aged 35–60 and men aged 45–60 in the general population | 120 mg | 20 mg | 30 mg | 2739 days | — |
| Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels? 2005 · daily antioxidant supplementation · French adults: women aged 35–60 years and men aged 45–60 years | 120 mg | 20 mg | 30 mg | 2739 days | — |
| Antioxidant supplementation increases the risk of skin cancers in women but not in men 2007 · antioxidant group · French adult women and men in a general-population primary-prevention trial | 120 mg | 20 mg | 30 mg | 2738 days | — |
| Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35 2013 · Antioxidants plus zinc · Adults aged 55–80 with age-related macular degeneration (AREDS categories 1–4) | 500 mg | 80 mg | 400 IU | 339 weeks | — |
| Micronutrient fortified milk improves iron status, anemia and growth among children 1-4 years: a double masked, randomized, controlled trial 2010 · Micronutrient-fortified milk (MN group) · Children aged 1–4 years in India; many had anemia, iron deficiency, or growth faltering | 40.2 mg | 7.8 mg | 7.5 mg | 1 year | 316 |
| A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study 2019 · verum group · Women aged 35–73 with healthy skin | 80 mg | 3 mg | 2.3 mg | 12 weeks | 36 |