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Vitamin C and Vitamin E: study protocols

38 study groups took Vitamin C together with Vitamin E. These are the doses the studies gave. They are not a recommendation.

Vitamin C: what the research found →

Dose per serving from research: Vitamin C

38 study groups in 26 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mg to 500 mg, 45% of 38 study groups.

Daily doseStudy groups
50 mg or less
1
50 mg to 100 mg
3
100 mg to 250 mg
9
250 mg to 500 mg
17
500 mg to 1 g
6
1 g to 2.5 g
2

Dose per serving from research: Vitamin E

20 study groups in 11 studies say how much Vitamin E participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 IU to 500 IU, 95% of 20 study groups.

Daily doseStudy groups
250 IU to 500 IU
19
over 500 IU
1

Commonly used together

30 of 38 study groups took Vitamin C and Vitamin E with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Zinc
20
Beta-Carotene
19
Copper
8
Selenium
8
Vitamin A
4

38 study groups

Study
Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis
2000 · combination of vitamins E and C · Smoking and nonsmoking men and postmenopausal women aged 45–69 years with serum cholesterol ≥5.0 mmol/L
500 mg182 mg3 years—
Supplementing vitamins C and E to standard triple therapy for the eradication of Helicobacter pylori
2012 · Group A · Patients with Helicobacter pylori infection
1 g400 IU30 days160
Supplementing vitamins C and E to standard triple therapy for the eradication of Helicobacter pylori
2012 · Group A · Patients with Helicobacter pylori infection
1 g400 IU30 days160
Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial
1999 · vitamin group · Women at increased risk of pre-eclampsia, enrolled at 16–22 weeks’ gestation
1 g400 IU—141
A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement
2013 · supplemented group · Patients scheduled for on-pump cardiac surgery; age and sex not specified
1 g400 IU—103
Oxidative stress in Helicobacter pylori infection: does supplementation with vitamins C and E increase the eradication rate?
2009 · group B · Patients with Helicobacter pylori infection; age range and sex not reported
1 g400 IU30 days80
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8
2001 · Antioxidants · Adults aged 55–80 with age-related macular degeneration Categories 2–4 and visual acuity of 20/32 or better in at least one eye
500 mg400 IU8 years—
Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13
2004 · antioxidants alone · Adults aged 55–81 years with age-related macular degeneration categories 1–4 or other AREDS ocular eligibility; participants in AMD categories 2–4 were eligible for this arm, and category 1 participants could also receive antioxidants
500 mg400 IU339 weeks—
Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT) trial
2005 · antioxidant vitamins · Adults with acute myocardial infarction; mean age 62 years
1.2 g600 mg30 days—
Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35
2013 · Antioxidants · Adults aged 55–80 with age-related macular degeneration (AREDS categories 1–4)
500 mg400 IU339 weeks—
Vitamin C and Vitamin E: study protocols | supp.fit