Vitamin C, Vitamin B6, Vitamin B12 and Folic Acid: study protocols
7 study groups took Vitamin C together with Vitamin B6, Vitamin B12 and Folic Acid. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin C
7 study groups in 6 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mg to 500 mg, 43% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 50 mg or less | 1 |
| 50 mg to 100 mg | 1 |
| 100 mg to 250 mg | 2 |
| 250 mg to 500 mg | 3 |
Dose per serving from research: Vitamin B6
7 study groups in 6 studies say how much Vitamin B6 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 43% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mg to 2.5 mg | 3 |
| 2.5 mg to 5 mg | 1 |
| 5 mg to 10 mg | 2 |
| 10 mg to 25 mg | 0 |
| 25 mg to 50 mg | 1 |
Dose per serving from research: Vitamin B12
7 study groups in 6 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mcg to 10 mcg, 43% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mcg or less | 1 |
| 2.5 mcg to 5 mcg | 2 |
| 5 mcg to 10 mcg | 3 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 0 |
| 50 mcg to 100 mcg | 0 |
| 100 mcg to 250 mcg | 0 |
| 250 mcg to 500 mcg | 1 |
Dose per serving from research: Folic Acid
7 study groups in 6 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 57% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mcg or less | 1 |
| 250 mcg to 500 mcg | 4 |
| 500 mcg to 1 mg | 1 |
| 1 mg to 2.5 mg | 0 |
| 2.5 mg to 5 mg | 1 |
Commonly used together
6 of 7 study groups took Vitamin C, Vitamin B6, Vitamin B12 and Folic Acid with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin E | 5 |
| Zinc | 5 |
| Magnesium | 3 |
| Riboflavin | 3 |
7 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males 2010 · multi-vitamin/mineral · Healthy males aged 30–55 years in full-time employment | 500 mg | 10 mg | 10 mcg | 400 mcg | 33 days | 103 |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 100 mg | 2.2 mg | 2.6 mcg | 400 mcg | — | — |
| Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation 2011 · Group MVB · Patients with type 2 diabetes | 200 mg | 10 mg | 10 mcg | 1 mg | 120 days | — |
| Low-dose B vitamins supplementation ameliorates cardiovascular risk: a double-blind randomized controlled trial in healthy Chinese elderly 2015 · treatment group · Healthy adults aged 60–74 years | 50 mg | 2 mg | 10 mcg | 400 mcg | 1 year | — |
| Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial 2006 · Antioxidant vitamins plus B-group vitamins · Acute ischemic stroke patients treated within 12 hours of symptom onset | 500 mg | 50 mg | 400 mcg | 5 mg | 2 weeks | 24 |
| Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study 2022 · TG1 · Hospitalized adults older than 65 years; sex not restricted; recruited for causes other than cancer, with specified immune-disease and infection exclusions | 135 mg | 2.1 mg | 2.5 mcg | 200 mcg | 12 weeks | 30 |
| Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study 2022 · TG2 · Hospitalized adults older than 65 years; sex not restricted; recruited for causes other than cancer, with specified immune-disease and infection exclusions | 270 mg | 4.2 mg | 5 mcg | 400 mcg | 6 weeks | 30 |