Vitamin B6, Vitamin B12, Folic Acid and Riboflavin: study protocols
7 study groups took Vitamin B6 together with Vitamin B12, Folic Acid and Riboflavin. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Vitamin B6
7 study groups in 6 studies say how much Vitamin B6 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg and 2.5 mg to 5 mg and 10 mg to 25 mg, 29% of 7 study groups each.
| Daily dose | Study groups |
|---|---|
| 1 mg to 2.5 mg | 2 |
| 2.5 mg to 5 mg | 2 |
| 5 mg to 10 mg | 1 |
| 10 mg to 25 mg | 2 |
Dose per serving from research: Vitamin B12
7 study groups in 6 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg and 5 mcg to 10 mcg and 25 mcg to 50 mcg, 29% of 7 study groups each.
| Daily dose | Study groups |
|---|---|
| 1 mcg to 2.5 mcg | 1 |
| 2.5 mcg to 5 mcg | 2 |
| 5 mcg to 10 mcg | 2 |
| 10 mcg to 25 mcg | 0 |
| 25 mcg to 50 mcg | 2 |
Dose per serving from research: Folic Acid
7 study groups in 6 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 43% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 2 |
| 250 mcg to 500 mcg | 3 |
| 500 mcg to 1 mg | 2 |
Dose per serving from research: Riboflavin
7 study groups in 6 studies say how much Riboflavin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 57% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mg to 2.5 mg | 4 |
| 2.5 mg to 5 mg | 1 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 2 |
Commonly used together
6 of 7 study groups took Vitamin B6, Vitamin B12, Folic Acid and Riboflavin with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin D | 3 |
| Zinc | 3 |
7 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 2.2 mg | 2.6 mcg | 400 mcg | 1.8 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women | 25 mg | 50 mcg | 800 mcg | 20 mg | — | — |
| Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension 2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women | 25 mg | 50 mcg | 800 mcg | 20 mg | — | — |
| A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status 2022 · B-vitamin treatment · Community-dwelling adults aged 50 years or older; men and women; no specific diagnosed condition, and not currently taking B-vitamin supplements at screening | 10 mg | 10 mcg | 200 mcg | 5 mg | 2 years | 103 |
| Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial 2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception | 2.6 mg | 5.2 mcg | 400 mcg | 1.8 mg | — | 870 |
| Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial 2016 · Normocis 400® group · Adults with stage 1 essential hypertension and hyper-homocysteinemia (HCys ≥15 μmol/L), without a history of cardiovascular or cerebrovascular disease; mean age 62.8 years, 63.5% male | 3 mg | 5 mcg | 400 mcg | 2.4 mg | 60 days | 52 |
| Effects of mixed dietary supplements on total plasma homocysteine concentrations (tHcy): a randomized, double-blind, placebo-controlled trial 2012 · supplement group · hospitalized, acutely ill older patients recovering from acute illness; sex and age range not stated | 1.4 mg | 1.5 mcg | 200 mcg | 1.3 mg | 6 weeks | — |