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Thiamine, Vitamin E, Vitamin B12 and Vitamin B6: study protocols

8 study groups took Thiamine together with Vitamin E, Vitamin B12 and Vitamin B6. These are the doses the studies gave. They are not a recommendation.

Thiamine: what the research found →

Dose per serving from research: Thiamine

8 study groups in 7 studies say how much Thiamine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 38% of 8 study groups.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
0
1 mg to 2.5 mg
3
2.5 mg to 5 mg
0
5 mg to 10 mg
1
10 mg to 25 mg
2
25 mg to 50 mg
1

Dose per serving from research: Vitamin E

8 study groups in 7 studies say how much Vitamin E participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mg to 10 mg and 10 mg to 25 mg and 25 mg to 50 mg, 25% of 8 study groups each.

Daily doseStudy groups
5 mg or less
1
5 mg to 10 mg
2
10 mg to 25 mg
2
25 mg to 50 mg
2
50 mg to 100 mg
1

Dose per serving from research: Vitamin B12

8 study groups in 7 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg and 25 mcg to 50 mcg, 25% of 8 study groups each.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
2
5 mcg to 10 mcg
1
10 mcg to 25 mcg
0
25 mcg to 50 mcg
2
50 mcg to 100 mcg
0
100 mcg to 250 mcg
0
250 mcg to 500 mcg
0
500 mcg to 1 mg
1

Dose per serving from research: Vitamin B6

8 study groups in 7 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg and 10 mg to 25 mg, 25% of 8 study groups each.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
0
1 mg to 2.5 mg
2
2.5 mg to 5 mg
1
5 mg to 10 mg
1
10 mg to 25 mg
2
25 mg to 50 mg
1

Commonly used together

8 of 8 study groups took Thiamine, Vitamin E, Vitamin B12 and Vitamin B6 with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Riboflavin
7
Folic Acid
5
Vitamin C
5
Zinc
5
Niacin
4
Vitamin A
4
Copper
3
Iron
3

8 study groups

Study
Effects of multimicronutrient supplementation on helminth reinfection: a randomized, controlled trial in Kenyan schoolchildren
2003 · multimicronutrient supplementation · Schoolchildren in Nyanza Province, Kenya; age and sex not specified
1.4 mg8 mg2 mcg1.7 mg335 days—
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
1.6 mg10 mg2.6 mcg2.2 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women
20 mg30 mg50 mcg25 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women
20 mg30 mg50 mcg25 mg——
Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy
2024 · 10-element combination tablet · Overweight or obese adults with type 2 diabetes and mild-to-moderate painful diabetic neuropathy; mean age 63 years
2.2 mg15 mg5 mcg3 mg26 weeks36
A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial
2023 · Ex PLUS® group · Healthy male and female non-athletes aged 20–30
33.6 mg16.8 mg750 mcg50 mg4 weeks32
Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation
2011 · Group MVB · Patients with type 2 diabetes
10 mg100 mg10 mcg10 mg120 days—
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial
2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies
500 mcg5 mg0.9 mcg500 mcg36 weeks130