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Thiamine, Folic Acid, Vitamin B12 and Vitamin B6: study protocols

7 study groups took Thiamine together with Folic Acid, Vitamin B12 and Vitamin B6. These are the doses the studies gave. They are not a recommendation.

Thiamine: what the research found →

Dose per serving from research: Thiamine

7 study groups in 5 studies say how much Thiamine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mg to 5 mg and 10 mg to 25 mg, 29% of 7 study groups each.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
0
1 mg to 2.5 mg
1
2.5 mg to 5 mg
2
5 mg to 10 mg
1
10 mg to 25 mg
2

Dose per serving from research: Folic Acid

7 study groups in 5 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 71% of 7 study groups.

Daily doseStudy groups
100 mcg to 250 mcg
1
250 mcg to 500 mcg
1
500 mcg to 1 mg
5

Dose per serving from research: Vitamin B12

7 study groups in 5 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mcg to 10 mcg, 43% of 7 study groups.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
0
2.5 mcg to 5 mcg
1
5 mcg to 10 mcg
3
10 mcg to 25 mcg
0
25 mcg to 50 mcg
2

Dose per serving from research: Vitamin B6

7 study groups in 5 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mg to 5 mg and 10 mg to 25 mg, 29% of 7 study groups each.

Daily doseStudy groups
1 mg or less
1
1 mg to 2.5 mg
1
2.5 mg to 5 mg
2
5 mg to 10 mg
1
10 mg to 25 mg
2

Commonly used together

7 of 7 study groups took Thiamine, Folic Acid, Vitamin B12 and Vitamin B6 with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Riboflavin
7
Vitamin E
5
Vitamin C
4
Vitamin A
3
Zinc
3

7 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
1.6 mg400 mcg2.6 mcg2.2 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women
20 mg800 mcg50 mcg25 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women
20 mg800 mcg50 mcg25 mg——
Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation
2011 · Group MVB · Patients with type 2 diabetes
10 mg1 mg10 mcg10 mg120 days—
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial
2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies
500 mcg150 mcg0.9 mcg500 mcg36 weeks130
A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels
2019 · Natural vitamin B complex (group N) · Healthy adults; age range and sex not specified
2.93 mg690 mcg8.85 mcg3.38 mg6 weeks30
A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels
2019 · Synthetic vitamin B complex (group S) · Healthy adults; age range and sex not specified
2.93 mg690 mcg8.85 mcg3.38 mg6 weeks30
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