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Thiamine and Folic Acid: study protocols

11 study groups took Thiamine together with Folic Acid. These are the doses the studies gave. They are not a recommendation.

Thiamine: what the research found →

Dose per serving from research: Thiamine

11 study groups in 9 studies say how much Thiamine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg and 2.5 mg to 5 mg and 10 mg to 25 mg, 18% of 11 study groups each.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
2
1 mg to 2.5 mg
1
2.5 mg to 5 mg
2
5 mg to 10 mg
1
10 mg to 25 mg
2
25 mg to 50 mg
1
50 mg to 100 mg
1

Dose per serving from research: Folic Acid

11 study groups in 9 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 45% of 11 study groups.

Daily doseStudy groups
100 mcg to 250 mcg
3
250 mcg to 500 mcg
1
500 mcg to 1 mg
5
1 mg to 2.5 mg
0
2.5 mg to 5 mg
1
5 mg to 10 mg
0
10 mg to 25 mg
0
over 25 mg
1

Commonly used together

9 of 11 study groups took Thiamine and Folic Acid with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Riboflavin
8
Vitamin B6
8
Vitamin B12
7
Vitamin E
5
Vitamin C
4
Vitamin A
3
Zinc
3

11 study groups

Study
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
1.6 mg400 mcg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women
20 mg800 mcg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women
20 mg800 mcg——
A pilot study of thiamin and folic acid in hemodialysis patients with cognitive impairment
2021 · Treatment group · Adults aged 18–80 with end-stage kidney disease receiving maintenance hemodialysis for at least 3 months and cognitive impairment
90 mg30 mg96 weeks25
Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale
1993 · fourth group · Patients with epilepsy receiving phenytoin alone or with phenobarbital for more than 4 years; age and sex not reported
50 mg5 mg26 weeks—
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
2025 · intervention group · Chinese adults with mild cognitive impairment; mean age 67.95 years; 70 male and 120 female
960 mcg180 mcg1 year95
Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation
2011 · Group MVB · Patients with type 2 diabetes
10 mg1 mg120 days—
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial
2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies
500 mcg150 mcg36 weeks130
Effect of B vitamins-fortified foods on primary school children in Beijing
2006 · B vitamin compound supplementation group · Normal primary school children aged 9–11 years
512 mcg130 mcg—33
A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels
2019 · Natural vitamin B complex (group N) · Healthy adults; age range and sex not specified
2.93 mg690 mcg6 weeks30
A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels
2019 · Synthetic vitamin B complex (group S) · Healthy adults; age range and sex not specified
2.93 mg690 mcg6 weeks30
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