Omega-3 Fatty Acids and Vitamin D: study protocols
12 study groups took Omega-3 Fatty Acids together with Vitamin D. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Omega-3 Fatty Acids
12 study groups in 11 studies say how much Omega-3 Fatty Acids participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 500 mg to 1 g, 75% of 12 study groups.
| Daily dose | Study groups |
|---|---|
| 500 mg to 1 g | 9 |
| 1 g to 2.5 g | 3 |
Dose per serving from research: Vitamin D
8 study groups in 8 studies say how much Vitamin D participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1,000 IU to 2,500 IU, 100% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 1,000 IU to 2,500 IU | 8 |
Commonly used together
2 of 12 study groups took Omega-3 Fatty Acids and Vitamin D with something else, but nothing that 3 or more different studies gave.
12 study groups
| Study | ||||
|---|---|---|---|---|
| Effect of Vitamin D3 Supplements on Development of Advanced Cancer: A Secondary Analysis of the VITAL Randomized Clinical Trial 2020 · Vitamin D3 and marine omega-3 fatty acids active · Men aged 50 years or older and women aged 55 years or older without cancer or cardiovascular disease at study entry | 1 g | 2,000 IU | 1937 days | — |
| Effects of vitamin D, omega-3 fatty acids, and a simple home strength exercise program on fall prevention: the DO-HEALTH randomized clinical trial 2022 · Vitamin D plus marine omega-3 supplementation (exercise assignment varied) · Community-dwelling adults aged 70 years and older, generally healthy and active, without major health events in the prior 5 years | 1 g | 2,000 IU | 3 years | — |
| Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease: A Novel Analysis of the VITAL Trial Using Win Ratio and Hierarchical Composite Outcomes 2023 · combination supplementation group · Men aged 50 years or older and women aged 55 years or older, free of known cardiovascular disease or cancer, from the general US population | 1 g | 2,000 IU | 1935 days | — |
| Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial 2024 · Vitamin D and n-3 fatty acids · Men aged 50 years or older and women aged 55 years or older, recruited from the United States; prevention population without the trial's excluded serious illnesses | 1 g | 2,000 IU | 1936 days | — |
| Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial 2021 · Group 4 Vitamin D + Omega-3 group · Women aged 15–50 with pre-diabetes and hypovitaminosis D | 2 g | — | 8 weeks | 42 |
| Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial 2015 · omega-3 group · Children aged 8–16 years living in the community | 2 g | 0.85 mcg | 26 weeks | 100 |
| Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial 2016 · Nutrition + CBT · Children aged 11–12 years at high risk for aggression or antisocial behavior, including full or borderline conduct disorder or oppositional defiant disorder criteria, or elevated proactive or reactive aggression scores | 1 g | — | 90 days | 73 |
| Nutritional supplementation to reduce child aggression: a randomized, stratified, single-blind, factorial trial 2016 · Nutrition only · Children aged 11–12 years at high risk for aggression or antisocial behavior, including full or borderline conduct disorder or oppositional defiant disorder criteria, or elevated proactive or reactive aggression scores | 1 g | — | 90 days | 72 |
| Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial 2020 · n-3 LCPUFA plus vitamin D · Pregnant women enrolled at pregnancy week 24; age range and health condition not specified | 2.4 g | 2,400 IU | 17 weeks | — |
| Effects of Vitamin D(3) and Marine Omega-3 Fatty Acids Supplementation on Biomarkers of Systemic Inflammation: 4-Year Findings from the VITAL Randomized Trial 2022 · Vitamin D3 and marine n-3 fatty acids active group · Men aged 50 years or older and women aged 55 years or older, without a history of cancer (except non-melanoma skin cancer), myocardial infarction, stroke, transient ischemic attack, or coronary revascularization | 1 g | 2,000 IU | 1935 days | — |