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Melatonin: study protocols

22 study groups say how much Melatonin participants took a day. These are the doses the studies gave. They are not a recommendation.

Melatonin: what the research found →

Dose per serving from products

3,861 products in our catalogue print how much Melatonin a serving holds.

Most common: 2.5 mg to 5 mg, 46% of 3,861 products.

Dose per servingProducts
500 mcg or less
113
500 mcg to 1 mg
448
1 mg to 2.5 mg
425
2.5 mg to 5 mg
1,760
5 mg to 10 mg
764
10 mg to 25 mg
183
over 25 mg
168

Dose per serving from research

18 study groups in 17 studies say how much Melatonin participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg and 2.5 mg to 5 mg, 39% of 18 study groups each.

Daily doseStudy groups
1 mg or less
1
1 mg to 2.5 mg
7
2.5 mg to 5 mg
7
5 mg to 10 mg
2
10 mg to 25 mg
1

Commonly used together

1 of 22 study groups took Melatonin with something else, but nothing that 3 or more different studies gave.

22 study groups

Study
Effects of Melatonin for Delirium in Elderly Acute Heart Failure Patients: A Randomized, Single-Center, Double-Blind, and Placebo-Controlled Trial
2022 · melatonin · Patients aged over 60 years after acute heart failure
3 mg7 days248
Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status
1999 · MLT plus chemotherapy · Adults with metastatic solid tumours and poor clinical status; age and sex not reported
20 mg—124
Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial
2016 · Melatonin treatment · Children and adolescents aged 1 to 18 years with physician-diagnosed atopic dermatitis involving at least 5% of total body surface area and sleep disturbance
3 mg4 weeks48
The effects of melatonin on follicular oxidative stress and art outcomes in women with diminished ovarian reserve: a randomized controlled trial
2025 · Melatonin intervention group · Infertile women with diminished ovarian reserve undergoing their first assisted reproductive technology cycle; age range not reported
3 mg—35
The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
2020 · melatonin · Diabetic hemodialysis patients aged 18–80 years
10 mg12 weeks30
Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial
2001 · melatonin · Children aged 6–12 years with chronic sleep onset insomnia lasting more than 1 year
5 mg4 weeks20
Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial
2003 · melatonin · Children aged 6–12 years with idiopathic chronic sleep-onset insomnia
5 mg4 weeks—
Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study
2015 · melatonin/hypothermia group · Term newborns with hypoxic-ischemic encephalopathy
10 mg/kg5 days15
Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety
2010 · prolonged-release melatonin (PRM) group · Men and women aged 18–80 years with primary insomnia; efficacy was also assessed in low melatonin excretors and adults aged 65–80 years.
2 mg29 weeks373
Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes
2007 · PR-melatonin · Males and females aged 55–80 years with primary insomnia
2 mg3 weeks177