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Lutein, Vitamin E and Zeaxanthin: study protocols

8 study groups took Lutein together with Vitamin E and Zeaxanthin. These are the doses the studies gave. They are not a recommendation.

Lutein: what the research found →

Dose per serving from research: Lutein

8 study groups in 7 studies say how much Lutein participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mg to 10 mg, 88% of 8 study groups.

Daily doseStudy groups
5 mg to 10 mg
7
10 mg to 25 mg
1

Dose per serving from research: Zeaxanthin

8 study groups in 7 studies say how much Zeaxanthin participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 63% of 8 study groups.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
2
1 mg to 2.5 mg
5

Commonly used together

8 of 8 study groups took Lutein, Vitamin E and Zeaxanthin with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin C
6
Zinc
6
Omega-3 Fatty Acids
4
Copper
3

8 study groups

Study
TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD
2007 · Sham MCS and nutritional supplement · Adults aged 50–90 with dry age-related macular degeneration in at least one eye
8 mg200 IU400 mcg24 weeks37
Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial
2022 · active group · Cognitively healthy adults aged 65 years and older
10 mg15 mg2 mg2 years30
Visual Function and Macular Carotenoid Changes in Eyes with Retinal Drusen-An Open Label Randomized Controlled Trial to Compare a Micronized Lipid-Based Carotenoid Liquid Supplementation and AREDS-2 Formula
2020 · PV group · Adults aged 54–80 with retinal drusen and risk of age-related macular degeneration
10 mg—2 mg26 weeks20
Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year
2008 · treated AMD (T-AMD) group · Patients with nonadvanced age-related macular degeneration; mean age 69.4 years
10 mg30 mg1 mg1 year15
Beneficial Effects of Micronutrient Supplementation in Restoring the Altered Microbiota and Gut-Retina Axis in Patients with Neovascular Age-Related Macular Degeneration-A Randomized Clinical Trial
2024 · intervention group · Adults with neovascular age-related macular degeneration; mean age 77.8 years
10 mg12 mg2 mg26 weeks15
Supplementation With Carotenoids, Omega-3 Fatty Acids, and Vitamin E Has a Positive Effect on the Symptoms and Progression of Alzheimer's Disease
2022 · active group · People with mild-moderate Alzheimer's disease; age and sex not reported
10 mg15 mg2 mg1 year50
Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study
2013 · D2 (twice daily) · Patients with non-exudative age-related macular degeneration; age and sex not specified
20 mg—2 mg1 year55
Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study
2013 · D1 (once daily) · Patients with non-exudative age-related macular degeneration; age and sex not specified
10 mg—1 mg1 year50
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