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Iron, Vitamin D, Vitamin B12, Vitamin B6 and Folic Acid: study protocols

9 study groups took Iron together with Vitamin D, Vitamin B12, Vitamin B6 and Folic Acid. These are the doses the studies gave. They are not a recommendation.

Iron: what the research found →

Dose per serving from research: Iron

9 study groups in 7 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 78% of 9 study groups.

Daily doseStudy groups
5 mg to 10 mg
1
10 mg to 25 mg
1
25 mg to 50 mg
7

Dose per serving from research: Vitamin D

5 study groups in 3 studies say how much Vitamin D participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 IU to 250 IU, 80% of 5 study groups.

Daily doseStudy groups
100 IU or less
1
100 IU to 250 IU
4

Dose per serving from research: Vitamin B12

8 study groups in 6 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 75% of 8 study groups.

Daily doseStudy groups
1 mcg or less
1
1 mcg to 2.5 mcg
0
2.5 mcg to 5 mcg
6
over 5 mcg
1

Dose per serving from research: Vitamin B6

9 study groups in 7 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 78% of 9 study groups.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
0
1 mg to 2.5 mg
7
over 2.5 mg
1

Dose per serving from research: Folic Acid

8 study groups in 6 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 88% of 8 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
7
500 mcg to 1 mg
1

Commonly used together

9 of 9 study groups took Iron, Vitamin D, Vitamin B12, Vitamin B6 and Folic Acid with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Iodine
8
Vitamin A
8
Vitamin C
8
Vitamin E
8
Zinc
8
Copper
7
Niacin
7
Selenium
7
Riboflavin
5

9 study groups

Study
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
30 mg200 IU2.6 mcg1.9 mg400 mcg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
30 mg200 IU2.6 mcg1.9 mg400 mcg——
Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial
2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation
30 mg5 mcg2.6 mcg1.9 mg400 mcg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
8.57 mg85.7 IU0.371 mcg271 mcg400 mcg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
30 mg200 IU2.6 mcg1.9 mg400 mcg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
30 mg200 IU2.6 mcg1.9 mg400 mcg180 days515
Associations of antenatal micronutrient supplementation with adolescent blood pressure: evidence from a 14-year follow-up study of a randomized controlled trial
2025 · Multiple micronutrients (MMNs; UNIMMAP formulation) · Pregnant women less than 28 weeks of gestation; offspring were followed up at ages 10–14 years
30 mg——1.9 mg———
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
12 mg10 mcg5.2 mcg2.6 mg400 mcg—870
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
27 mg5 mcg2.6 mcg1.9 mg600 mcg—176