Iron, Vitamin B6, Vitamin C and Folic Acid: study protocols
9 study groups took Iron together with Vitamin B6, Vitamin C and Folic Acid. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Iron
9 study groups in 7 studies say how much Iron participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 78% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg to 10 mg | 2 |
| 10 mg to 25 mg | 0 |
| 25 mg to 50 mg | 7 |
Dose per serving from research: Vitamin B6
9 study groups in 7 studies say how much Vitamin B6 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 1 mg to 2.5 mg, 78% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mcg to 500 mcg | 2 |
| 500 mcg to 1 mg | 0 |
| 1 mg to 2.5 mg | 7 |
Dose per serving from research: Vitamin C
9 study groups in 7 studies say how much Vitamin C participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 50 mg to 100 mg, 78% of 9 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mg or less | 1 |
| 10 mg to 25 mg | 0 |
| 25 mg to 50 mg | 1 |
| 50 mg to 100 mg | 7 |
Dose per serving from research: Folic Acid
8 study groups in 6 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 75% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg to 250 mcg | 1 |
| 250 mcg to 500 mcg | 6 |
| 500 mcg to 1 mg | 1 |
Commonly used together
9 of 9 study groups took Iron, Vitamin B6, Vitamin C and Folic Acid with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin A | 9 |
| Vitamin B12 | 9 |
| Vitamin E | 9 |
| Copper | 8 |
| Iodine | 8 |
| Selenium | 8 |
| Vitamin D | 8 |
| Zinc | 8 |
| Niacin | 7 |
| Riboflavin | 4 |
9 study groups
| Study | ||||||
|---|---|---|---|---|---|---|
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 30 mg | 1.9 mg | 70 mg | 400 mcg | — | — |
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 30 mg | 1.9 mg | 70 mg | 400 mcg | — | — |
| Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial 2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation | 30 mg | 1.9 mg | 70 mg | 400 mcg | — | — |
| Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam 2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant | 8.57 mg | 271 mcg | 10 mg | 400 mcg | 54 weeks | 1,469 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 30 mg | 1.9 mg | 70 mg | 400 mcg | 180 days | 516 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 30 mg | 1.9 mg | 70 mg | 400 mcg | 180 days | 515 |
| Associations of antenatal micronutrient supplementation with adolescent blood pressure: evidence from a 14-year follow-up study of a randomized controlled trial 2025 · Multiple micronutrients (MMNs; UNIMMAP formulation) · Pregnant women less than 28 weeks of gestation; offspring were followed up at ages 10–14 years | 30 mg | 1.9 mg | 70 mg | — | — | — |
| Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh 2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified | 27 mg | 1.9 mg | 85 mg | 600 mcg | — | 176 |
| Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial 2021 · intervention · Children aged 6–9 years, apparently healthy, in rural Hai Phong City, Vietnam; included undernourished, normal-weight, and overweight/obese children | 10 mg | 500 mcg | 30 mg | 150 mcg | 22 weeks | 175 |