Iron, Vitamin B12, Vitamin E, Folic Acid and Niacin: study protocols
7 study groups took Iron together with Vitamin B12, Vitamin E, Folic Acid and Niacin. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Iron
7 study groups in 5 studies say how much Iron participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 25 mg to 50 mg, 86% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 10 mg or less | 1 |
| 10 mg to 25 mg | 0 |
| 25 mg to 50 mg | 6 |
Dose per serving from research: Vitamin B12
6 study groups in 4 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 83% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 0.5 mcg or less | 1 |
| 0.5 mcg to 1 mcg | 0 |
| 1 mcg to 2.5 mcg | 0 |
| 2.5 mcg to 5 mcg | 5 |
Dose per serving from research: Vitamin E
7 study groups in 5 studies say how much Vitamin E participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 5 mg to 10 mg, 86% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mg or less | 1 |
| 2.5 mg to 5 mg | 0 |
| 5 mg to 10 mg | 6 |
Dose per serving from research: Folic Acid
6 study groups in 4 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 100% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 250 mcg to 500 mcg | 6 |
Dose per serving from research: Niacin
7 study groups in 5 studies say how much Niacin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 86% of 7 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 6 |
Commonly used together
7 of 7 study groups took Iron, Vitamin B12, Vitamin E, Folic Acid and Niacin with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Vitamin A | 7 |
| Vitamin B6 | 7 |
| Vitamin C | 7 |
| Vitamin D | 7 |
| Copper | 6 |
| Iodine | 6 |
| Selenium | 6 |
| Zinc | 6 |
| Riboflavin | 4 |
7 study groups
| Study | |||||||
|---|---|---|---|---|---|---|---|
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 30 mg | 2.6 mcg | 10 mg | 400 mcg | 18 mg | — | — |
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 30 mg | 2.6 mcg | 10 mg | 400 mcg | 18 mg | — | — |
| Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial 2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation | 30 mg | 2.6 mcg | 10 mg | 400 mcg | 18 mg | — | — |
| Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam 2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant | 8.57 mg | 0.371 mcg | 1.43 mg | 400 mcg | 2.57 mg | 54 weeks | 1,469 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 30 mg | 2.6 mcg | 10 mg | 400 mcg | 18 mg | 180 days | 516 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 30 mg | 2.6 mcg | 10 mg | 400 mcg | 18 mg | 180 days | 515 |
| Associations of antenatal micronutrient supplementation with adolescent blood pressure: evidence from a 14-year follow-up study of a randomized controlled trial 2025 · Multiple micronutrients (MMNs; UNIMMAP formulation) · Pregnant women less than 28 weeks of gestation; offspring were followed up at ages 10–14 years | 30 mg | — | 10 mg | — | 18 mg | — | — |