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Iron, Folic Acid, Vitamin B12, Vitamin B6 and Riboflavin: study protocols

5 study groups took Iron together with Folic Acid, Vitamin B12, Vitamin B6 and Riboflavin. These are the doses the studies gave. They are not a recommendation.

Iron: what the research found →

Dose per serving from research: Iron

5 study groups in 4 studies say how much Iron participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 60% of 5 study groups.

Daily doseStudy groups
5 mg to 10 mg
1
10 mg to 25 mg
1
25 mg to 50 mg
3

Dose per serving from research: Folic Acid

5 study groups in 4 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 100% of 5 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
5

Dose per serving from research: Vitamin B12

5 study groups in 4 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 2.5 mcg to 5 mcg, 60% of 5 study groups.

Daily doseStudy groups
0.5 mcg or less
1
0.5 mcg to 1 mcg
0
1 mcg to 2.5 mcg
0
2.5 mcg to 5 mcg
3
over 5 mcg
1

Dose per serving from research: Vitamin B6

5 study groups in 4 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 60% of 5 study groups.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
0
1 mg to 2.5 mg
3
over 2.5 mg
1

Dose per serving from research: Riboflavin

5 study groups in 4 studies say how much Riboflavin participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 80% of 5 study groups.

Daily doseStudy groups
250 mcg or less
1
250 mcg to 500 mcg
0
500 mcg to 1 mg
0
1 mg to 2.5 mg
4

Commonly used together

5 of 5 study groups took Iron, Folic Acid, Vitamin B12, Vitamin B6 and Riboflavin with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin D
5
Iodine
4
Niacin
4
Vitamin A
4
Vitamin C
4
Vitamin E
4
Zinc
4

5 study groups

Study
Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial
2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation
30 mg400 mcg2.6 mcg1.9 mg1.4 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
8.57 mg400 mcg0.371 mcg271 mcg200 mcg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
30 mg400 mcg2.6 mcg1.9 mg1.4 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
30 mg400 mcg2.6 mcg1.9 mg1.4 mg180 days515
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
2023 · intervention · Women planning pregnancy; generally healthy, recruited before conception
12 mg400 mcg5.2 mcg2.6 mg1.8 mg—870