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Vitamin B9, Vitamin B6 and Vitamin B12: study protocols

14 study groups took Vitamin B9 together with Vitamin B6 and Vitamin B12. These are the doses the studies gave. They are not a recommendation.

Vitamin B9: what the research found →

Dose per serving from research: Vitamin B9

14 study groups in 11 studies say how much Vitamin B9 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 36% of 14 study groups.

Daily doseStudy groups
250 mcg or less
1
250 mcg to 500 mcg
2
500 mcg to 1 mg
2
1 mg to 2.5 mg
1
2.5 mg to 5 mg
2
5 mg to 10 mg
1
10 mg to 25 mg
5

Dose per serving from research: Vitamin B6

13 study groups in 10 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 25 mg to 50 mg, 46% of 13 study groups.

Daily doseStudy groups
1 mg or less
1
1 mg to 2.5 mg
1
2.5 mg to 5 mg
4
5 mg to 10 mg
0
10 mg to 25 mg
0
25 mg to 50 mg
6
50 mg to 100 mg
1

Dose per serving from research: Vitamin B12

14 study groups in 11 studies say how much Vitamin B12 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 43% of 14 study groups.

Daily doseStudy groups
1 mcg to 2.5 mcg
1
2.5 mcg to 5 mcg
1
5 mcg to 10 mcg
2
10 mcg to 25 mcg
2
25 mcg to 50 mcg
0
50 mcg to 100 mcg
0
100 mcg to 250 mcg
0
250 mcg to 500 mcg
2
500 mcg to 1 mg
6

Commonly used together

6 of 14 study groups took Vitamin B9, Vitamin B6 and Vitamin B12 with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin D
4

14 study groups

Study
B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.OM3 randomized trial
2014 · B vitamins only · Adults aged 45–80 with a recent history of myocardial infarction, unstable angina, or ischemic stroke
560 mcg3 mg20 mcg1716 days—
Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study
2022 · Mg-Teadiola · Adults aged 18–65, either sex, otherwise healthy and chronically stressed (DASS-42 stress score ≥14)
100 mcg700 mcg1.25 mcg4 weeks51
B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.OM3 randomized trial
2014 · B vitamins plus n-3 fatty acids · Adults aged 45–80 with a recent history of myocardial infarction, unstable angina, or ischemic stroke
560 mcg3 mg20 mcg1716 days—
Distribution of plasma folate forms in hemodialysis patients receiving high daily doses of L-folinic or folic acid
2002 · Folinic acid group · Adults with chronic stable hemodialysis and hyperhomocysteinemia
20 mg50 mg1 mg12 weeks22
Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (Soloways(TM)) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial
2024 · methylfolate, P5P, and methylcobalamin · Adults aged 40–75 with elevated homocysteine, LDL-C of 70–190 mg/dL, and at least one minor allele in a specified MTHFR, MTR, or MTRR polymorphism
2 mg100 mg1 mg180 days27
Controlled comparison of L-5-methyltetrahydrofolate versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients
2000 · MTHF group · Adults with chronic, stable hyperhomocysteinemia receiving hemodialysis
17 mg50 mg1 mg12 weeks25
Treatment of hyperhomocysteinemia in hemodialysis patients and renal transplant recipients
2001 · MTHF group · Adults with chronic, stable hyperhomocysteinemia receiving maintenance hemodialysis
17 mg50 mg1 mg12 weeks25
Rapid communication: L-folinic acid versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients
2001 · L-folinic acid group · Adults with chronic, stable hyperhomocysteinemia receiving hemodialysis
20 mg50 mg1 mg12 weeks24
Treatment of hyperhomocysteinemia in hemodialysis patients and renal transplant recipients
2001 · Hemodialysis patients receiving MTHF · Hemodialysis patients with hyperhomocysteinemia and baseline total homocysteine comparable to the renal transplant recipients
17 mg50 mg1 mg12 weeks—
Hyperhomocysteinaemia therapy in haemodialysis patients: folinic versus folic acid in combination with vitamin B6 and B12
2002 · Group 2 · Chronic haemodialysis patients; age and sex not specified
7.14 mg—429 mcg26 weeks—
Effects of prenatal micronutrient and early food supplementation on metabolic status of the offspring at 4.5 years of age. The MINIMat randomized trial in rural Bangladesh
2016 · MMS · Pregnant women in rural Bangladesh; offspring assessed at 4.5 years
400 mcg1.9 mg2.6 mcg—439
Maternal cortisol and stress are associated with birth outcomes, but are not affected by lipid-based nutrient supplements during pregnancy: an analysis of data from a randomized controlled trial in rural Malawi
2015 · LNS · Pregnant women aged 15–49 years in rural Malawi, enrolled at up to 20 weeks of gestation
2.8 mg3.8 mg5.2 mcg—418
Maternal cortisol and stress are associated with birth outcomes, but are not affected by lipid-based nutrient supplements during pregnancy: an analysis of data from a randomized controlled trial in rural Malawi
2015 · MMN · Pregnant women aged 15–49 years in rural Malawi, enrolled at up to 20 weeks of gestation
2.8 mg3.8 mg5.2 mcg—415
Effect of adding B-vitamins to vitamin D and calcium supplementation on CpG methylation of epigenetic aging markers
2018 · D + Ca + B · Adults, mean age 68.4 years; no specific condition stated
500 mcg50 mg500 mcg1 year32
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