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St. John's Wort: study protocols

21 study groups say how much St. John's Wort participants took a day. These are the doses the studies gave. They are not a recommendation.

St. John's Wort: what the research found →

Dose per serving from products

232 products in our catalogue print how much St. John's Wort a serving holds.

Most common: 100 mg to 250 mg, 47% of 232 products.

Dose per servingProducts
25 mg or less
10
25 mg to 50 mg
24
50 mg to 100 mg
19
100 mg to 250 mg
108
250 mg to 500 mg
38
500 mg to 1 g
30
over 1 g
3

Dose per serving from research

21 study groups in 10 studies say how much St. John's Wort participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mg to 1 g, 48% of 21 study groups.

Daily doseStudy groups
250 mcg or less
1
250 mcg to 500 mcg
1
500 mcg to 1 mg
1
1 mg to 2.5 mg
0
2.5 mg to 5 mg
0
5 mg to 10 mg
0
10 mg to 25 mg
0
25 mg to 50 mg
1
50 mg to 100 mg
0
100 mg to 250 mg
0
250 mg to 500 mg
1
500 mg to 1 g
10
1 g to 2.5 g
3
2.5 g to 5 g
3

Commonly used together

None of these 21 study groups took St. John's Wort with anything else.

21 study groups

Study
Continuation and long-term maintenance treatment with Hypericum extract WS 5570 after recovery from an acute episode of moderate depression--a double-blind, randomized, placebo controlled long-term trial
2008 · WS 5570 · Adults with recurrent moderate major depression who had recovered after an acute episode; at least three previous episodes in five years
900 mg26 weeks282
Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial
2002 · WS 5570 · Adult male and female outpatients with mild to moderate major depression, single or recurrent episode, meeting DSM-IV criteria
900 mg6 weeks186
Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]
2006 · WS 5570 600 mg/day · Men and women aged 18–65 with a mild or moderate major depressive episode and baseline HAM-D score ≥18
600 mg6 weeks123
Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial
2003 · cycle A · healthy females
600 mg—17
Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial
2003 · cycle B · healthy females
900 mg—17
Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression: a double-blind, randomised, multicentre, placebo-controlled study
2006 · hypericum extract STW3-VI · Outpatients with moderate depression; age and sex not reported
900 mg6 weeks—
Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]
2006 · WS 5570 1200 mg/day · Men and women aged 18–65 with a mild or moderate major depressive episode and baseline HAM-D score ≥18
1.2 g6 weeks127
A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoot tips of Hypericum perforatum L
1999 · 1 mg group · Adult outpatients with mild to moderate depression
1 mg6 weeks119
A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoot tips of Hypericum perforatum L
1999 · 0.33 mg group · Adult outpatients with mild to moderate depression
330 mcg6 weeks115
A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoot tips of Hypericum perforatum L
1999 · 0.17 mg group · Adult outpatients with mild to moderate depression
170 mcg6 weeks114