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Probiotics and Prebiotics: study protocols

11 study groups took Probiotics together with Prebiotics. These are the doses the studies gave. They are not a recommendation.

Probiotics: what the research found →

Dose per serving from research: Probiotics

10 study groups in 10 studies say how much Probiotics participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 billion CFU to 25 billion CFU, 30% of 10 study groups.

Daily doseStudy groups
0.05 billion CFU or less
1
0.05 billion CFU to 0.1 billion CFU
1
0.1 billion CFU to 0.25 billion CFU
0
0.25 billion CFU to 0.5 billion CFU
0
0.5 billion CFU to 1 billion CFU
1
1 billion CFU to 2.5 billion CFU
1
2.5 billion CFU to 5 billion CFU
1
5 billion CFU to 10 billion CFU
2
10 billion CFU to 25 billion CFU
3

Dose per serving from research: Prebiotics

6 study groups in 6 studies say how much Prebiotics participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mg to 1 g, 33% of 6 study groups.

Daily doseStudy groups
250 mg or less
1
250 mg to 500 mg
0
500 mg to 1 g
2
1 g to 2.5 g
1
2.5 g to 5 g
0
5 g to 10 g
1
10 g to 25 g
1

Commonly used together

1 of 11 study groups took Probiotics and Prebiotics with something else, but nothing that 3 or more different studies gave.

11 study groups

Study
Prebiotic and probiotic fortified milk in prevention of morbidities among children: community-based, randomized, double-blind, controlled trial
2010 · Prebiotic and probiotic fortified milk (PP) · Children aged 1–4 years in a community setting in India, with no specific diagnosed condition required
0.019 billion CFU2.4 g1 year312
Effects of synbiotics on necrotizing enterocolitis and full enteral feeding in very low birth weight infants: A double-blind, randomized controlled trial
2024 · Synbiotic group · Preterm neonates with very low birth weight under 1500 g and gestational age under 34 weeks
2 billion CFU——59
Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial
2018 · Synbiotics group · Patients older than 16 years with sepsis requiring mechanical ventilation in the ICU
3 g10 g20 days35
Perioperative synbiotics decrease postoperative complications in periampullary neoplasms: a randomized, double-blind clinical trial
2015 · group S (synbiotics) · Adults undergoing surgery for periampullary neoplasms; age and sex not specified
8 billion CFU200 mg2 weeks23
A synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong (RECOVERY): a randomised, double-blind, placebo-controlled trial
2024 · SIM01 · Adults with post-acute COVID-19 syndrome (PACS), with at least one PACS symptom persisting for 4 weeks or more after confirmed SARS-CoV-2 infection
20 billion CFU—26 weeks232
Effectiveness of a Balanced Nine-Strain Synbiotic in Primary-Care Irritable Bowel Syndrome Patients-A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial
2024 · multi-strain synbiotic group · Female and male patients aged 18–65 years with moderate to severe irritable bowel syndrome
4.5 billion CFU—12 weeks101
Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial
2023 · Group D · Adults aged 18–70 with functional constipation
19.2 billion CFU960 mg4 weeks50
Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial
2025 · synbiotic group · Adults aged 60 years or older with functional constipation by Rome IV criteria and no significant comorbidities
20 billion CFU800 mg4 weeks34
Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial
2016 · LU + B420 · Adults aged 18–65 with overweight or obesity (BMI 28.0–34.9)
10 billion CFU12 g26 weeks—
A young child formula with Limosilactobacillus reuteri and GOS modulates gut microbiome and enhances bone and muscle development: a randomized trial
2025 · experimental young child formula (EYCF) · Healthy Filipino boys and girls aged 24–36 months
0.1 billion CFU—26 weeks91