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N-Acetyl Cysteine and Vitamin C: study protocols

8 study groups took N-Acetyl Cysteine together with Vitamin C. These are the doses the studies gave. They are not a recommendation.

N-Acetyl Cysteine: what the research found →

Dose per serving from research: N-Acetyl Cysteine

8 study groups in 6 studies say how much N-Acetyl Cysteine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 g to 1,000 g, 38% of 8 study groups.

Daily doseStudy groups
100 mg to 250 mg
2
250 mg to 500 mg
0
500 mg to 1 g
1
1 g to 2.5 g
2
2.5 g to 5 g
0
5 g to 10 g
0
10 g to 25 g
0
25 g to 50 g
0
50 g to 100 g
0
100 g to 250 g
0
250 g to 500 g
0
500 g to 1,000 g
3

Dose per serving from research: Vitamin C

7 study groups in 5 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mg to 250 mg, 71% of 7 study groups.

Daily doseStudy groups
100 mg to 250 mg
5
250 mg to 500 mg
0
500 mg to 1 g
0
1 g to 2.5 g
0
2.5 g to 5 g
1
5 g to 10 g
1

Commonly used together

7 of 8 study groups took N-Acetyl Cysteine and Vitamin C with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Vitamin E
5

8 study groups

Study
Effect of antioxidant therapy on hospital stay and complications in patients with early acute pancreatitis: a randomised controlled trial
2009 · SMT + AO · Adults admitted within 72 hours of onset of pain with acute pancreatitis; age and sex not specified
600 mg——23
N-acetylcysteine and/or ascorbic acid versus placebo to prevent contrast-induced nephropathy in patients undergoing elective cardiac catheterization: The NAPCIN trial; A single-center, prospective, randomized trial
2016 · Group B · High-risk patients undergoing elective cardiac catheterization
1.2 g7 g—30
Lower rate of preeclampsia after antioxidant supplementation in pregnant women with low antioxidant status
2006 · supplementation group · Pregnant women screened positive for low antioxidant status at 8 to 12 weeks of gestation
200 mg200 mg—29
Mechanical Ventilation Antioxidant Trial
2015 · vitamin C plus vitamin E plus N-acetylcysteine · critically ill adults requiring mechanical ventilation
1.2 g3 g——
Effects of Macuprev(®) Supplementation in Age-Related Macular Degeneration: A Double-Blind Randomized Morpho-Functional Study Along 6 Months of Follow-Up
2019 · AMD-M group · Adults with intermediate age-related macular degeneration; 9 male and 21 female enrolled overall, mean age 69.32 years
140 mg160 mg26 weeks15
Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: a single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls
2005 · type 2 diabetes group · Adults with early-stage, untreated type 2 diabetes
600 g250 mg15 days46
Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: a single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls
2005 · impaired glucose tolerance group · Adults with impaired glucose tolerance
600 g250 mg15 days46
Effects of antioxidant supplementation on postprandial oxidative stress and endothelial dysfunction: a single-blind, 15-day clinical trial in patients with untreated type 2 diabetes, subjects with impaired glucose tolerance, and healthy controls
2005 · healthy control group · Healthy adults
600 g250 mg15 days46
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