L-Methionine and Vitamin C: study protocols

5 study groups took L-Methionine together with Vitamin C. These are the doses the studies gave. They are not a recommendation.

Fewer than 5 study groups in one unit match, too few to draw the chart.

Dose per serving from research: Vitamin C

5 study groups in 5 studies say how much Vitamin C participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mg to 1 g, 80% of 5 study groups.

Daily dose	Study groups
500 mg to 1 g	4
1 g to 2.5 g	1

3 of 5 study groups took L-Methionine and Vitamin C with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken with	Study groups
Vitamin E	3

5 study groups

Study
Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy 1999 · oral methionine preceded by vitamin C · Healthy adults aged 21–59 years; 10 male and 7 female; no stated condition	100 mg/kg	1 g	7 days	17
Impairment of coronary circulation by acute hyperhomocysteinaemia and reversal by antioxidant vitamins 2004 · methionine load with antioxidant vitamins · Healthy volunteers aged 26–40 years; nine men and seven women, with no stated condition	100 mg/kg	1 g	1 day	16
Acute methionine loading does not alter arterial stiffness in humans 2001 · methionine plus vitamin C · healthy men, mean age 29 years (range 20–42)	100 mg/kg	2 g	1 day	8
Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins 1999 · Methionine load with antioxidant vitamins · Healthy adults aged 25 to 45 years; 10 men and 10 women	100 mg/kg	1 g	1 day	20
Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial 1992 · active treatment · Patients with recurrent non-gallstone pancreatitis	2 g	540 mg	10 weeks	20