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Folic Acid, Zinc, Vitamin E and Vitamin A: study protocols

14 study groups took Folic Acid together with Zinc, Vitamin E and Vitamin A. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

14 study groups in 11 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 71% of 14 study groups.

Daily doseStudy groups
100 mcg or less
1
100 mcg to 250 mcg
1
250 mcg to 500 mcg
10
500 mcg to 1 mg
2

Dose per serving from research: Zinc

14 study groups in 11 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 57% of 14 study groups.

Daily doseStudy groups
5 mg or less
1
5 mg to 10 mg
2
10 mg to 25 mg
8
25 mg to 50 mg
3

Dose per serving from research: Vitamin E

14 study groups in 11 studies say how much Vitamin E participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mg to 10 mg, 50% of 14 study groups.

Daily doseStudy groups
2.5 mg or less
1
2.5 mg to 5 mg
1
5 mg to 10 mg
7
10 mg to 25 mg
5

Dose per serving from research: Vitamin A

13 study groups in 10 studies say how much Vitamin A participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 500 mcg to 1 mg, 69% of 13 study groups.

Daily doseStudy groups
250 mcg or less
1
250 mcg to 500 mcg
1
500 mcg to 1 mg
9
1 mg to 2.5 mg
2

Commonly used together

14 of 14 study groups took Folic Acid, Zinc, Vitamin E and Vitamin A with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.

What was given together, not what works together.

Taken withStudy groups
Copper
14
Iodine
13
Iron
13
Selenium
13
Vitamin C
13
Vitamin D
13
Niacin
12
Vitamin B12
11
Vitamin B6
10
Riboflavin
8

14 study groups

Study
Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial
2008 · Multiple micronutrients · Pregnant women resident in disadvantaged rural counties in Shaanxi Province, China; eligible women enrolled before 28 weeks’ gestation
400 mcg15 mg10 mg800 mcg—1,899
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg15 mg10 mg800 mcg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg15 mg10 mg800 mcg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
400 mcg30 mg10 mg1 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg2.14 mg1.43 mg114 mcg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg15 mg10 mg800 mcg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg15 mg10 mg800 mcg180 days515
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
600 mcg12 mg15 mg770 mcg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
600 mcg12 mg15 mg770 mcg—176
Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B(12) status among young Laotian children: a randomized controlled trial
2022 · micronutrient powder group (MNP) · Children aged 6–23 months in rural Lao PDR; no disease-based selection, with high prevalence of undernutrition and micronutrient deficiencies
150 mcg10 mg5 mg400 mcg36 weeks130