Folic Acid, Zinc, Vitamin B12, Niacin and Vitamin D: study protocols
8 study groups took Folic Acid together with Zinc, Vitamin B12, Niacin and Vitamin D. These are the doses the studies gave. They are not a recommendation.
Dose per serving from research: Folic Acid
8 study groups in 6 studies say how much Folic Acid participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 250 mcg to 500 mcg, 88% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 100 mcg or less | 1 |
| 100 mcg to 250 mcg | 0 |
| 250 mcg to 500 mcg | 7 |
Dose per serving from research: Zinc
8 study groups in 6 studies say how much Zinc participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 63% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 2.5 mg or less | 1 |
| 2.5 mg to 5 mg | 0 |
| 5 mg to 10 mg | 1 |
| 10 mg to 25 mg | 5 |
| over 25 mg | 1 |
Dose per serving from research: Vitamin B12
8 study groups in 6 studies say how much Vitamin B12 participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 2.5 mcg to 5 mcg, 75% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 1 mcg or less | 1 |
| 1 mcg to 2.5 mcg | 1 |
| 2.5 mcg to 5 mcg | 6 |
Dose per serving from research: Niacin
8 study groups in 6 studies say how much Niacin participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 10 mg to 25 mg, 88% of 8 study groups.
| Daily dose | Study groups |
|---|---|
| 5 mg or less | 1 |
| 5 mg to 10 mg | 0 |
| 10 mg to 25 mg | 7 |
Dose per serving from research: Vitamin D
6 study groups in 4 studies say how much Vitamin D participants took a day.
These are the doses the studies gave. They are not a recommendation.
Most common: 100 IU to 250 IU, 67% of 6 study groups.
| Daily dose | Study groups |
|---|---|
| 100 IU or less | 1 |
| 100 IU to 250 IU | 4 |
| 250 IU to 500 IU | 1 |
Commonly used together
8 of 8 study groups took Folic Acid, Zinc, Vitamin B12, Niacin and Vitamin D with something else. Shown: what 3 or more different studies gave.
What was given together, not what works together.
| Taken with | Study groups |
|---|---|
| Copper | 8 |
| Vitamin A | 8 |
| Vitamin B6 | 8 |
| Vitamin C | 8 |
| Vitamin E | 8 |
| Iodine | 7 |
| Iron | 7 |
| Selenium | 7 |
| Riboflavin | 5 |
| Thiamine | 3 |
8 study groups
| Study | |||||||
|---|---|---|---|---|---|---|---|
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 400 mcg | 15 mg | 2.6 mcg | 18 mg | 200 IU | — | — |
| Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh 2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation | 400 mcg | 15 mg | 2.6 mcg | 18 mg | 200 IU | — | — |
| Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal 2003 · Multiple micronutrients · Pregnant women in rural Nepal | 400 mcg | 30 mg | 2.6 mcg | 20 mg | 10 mcg | — | — |
| Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam 2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant | 400 mcg | 2.14 mg | 0.371 mcg | 2.57 mg | 85.7 IU | 54 weeks | 1,469 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 400 mcg | 15 mg | 2.6 mcg | 18 mg | 200 IU | 180 days | 516 |
| Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia 2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy | 400 mcg | 15 mg | 2.6 mcg | 18 mg | 200 IU | 180 days | 515 |
| Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial 2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years | 40 mcg | 10 mg | 2.4 mcg | 16 mg | 400 IU | 26 weeks | 104 |
| A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia 2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population | 400 mcg | 15 mg | 2.6 mcg | 18 mg | — | 12 weeks | 105 |