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Folic Acid, Zinc, Iodine, Vitamin D and Copper: study protocols

12 study groups took Folic Acid together with Zinc, Iodine, Vitamin D and Copper. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

12 study groups in 9 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 75% of 12 study groups.

Daily doseStudy groups
100 mcg or less
1
100 mcg to 250 mcg
0
250 mcg to 500 mcg
9
500 mcg to 1 mg
2

Dose per serving from research: Zinc

12 study groups in 9 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 67% of 12 study groups.

Daily doseStudy groups
5 mg or less
1
5 mg to 10 mg
1
10 mg to 25 mg
8
25 mg to 50 mg
2

Dose per serving from research: Iodine

12 study groups in 9 studies say how much Iodine participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 mcg to 250 mcg, 75% of 12 study groups.

Daily doseStudy groups
50 mcg or less
1
50 mcg to 100 mcg
0
100 mcg to 250 mcg
9
250 mcg to 500 mcg
2

Dose per serving from research: Vitamin D

8 study groups in 5 studies say how much Vitamin D participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 100 IU to 250 IU, 50% of 8 study groups.

Daily doseStudy groups
100 IU or less
1
100 IU to 250 IU
4
250 IU to 500 IU
3

Dose per serving from research: Copper

12 study groups in 9 studies say how much Copper participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 50% of 12 study groups.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
3
1 mg to 2.5 mg
6
2.5 mg to 5 mg
2

Commonly used together

12 of 12 study groups took Folic Acid, Zinc, Iodine, Vitamin D and Copper with something else. Shown: what 3 or more different studies gave.

What was given together, not what works together.

Taken withStudy groups
Selenium
12
Vitamin A
12
Vitamin C
12
Vitamin E
12
Iron
11
Niacin
10
Vitamin B12
9
Vitamin B6
8
Riboflavin
6
vitamin B-6
4

12 study groups

Study
Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial
2008 · Multiple micronutrients · Pregnant women resident in disadvantaged rural counties in Shaanxi Province, China; eligible women enrolled before 28 weeks’ gestation
400 mcg15 mg150 mcg5 mcg2 mg—1,899
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg15 mg150 mcg200 IU2 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg15 mg150 mcg200 IU2 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg2.14 mg21.4 mcg85.7 IU286 mcg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg15 mg150 mcg200 IU2 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg15 mg150 mcg200 IU2 mg180 days515
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
600 mcg12 mg220 mcg5 mcg1 mg165 days749
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
600 mcg12 mg220 mcg5 mcg1 mg—176
Multiple micronutrient supplementation improves vitamin B₁₂ and folate concentrations of HIV infected children in Uganda: a randomized controlled trial
2011 · Multiple micronutrient supplementation (MMS) · HIV-infected children aged 1–5 years
40 mcg10 mg180 mcg400 IU800 mcg26 weeks104
mRNA Levels of Placental Iron and Zinc Transporter Genes Are Upregulated in Gambian Women with Low Iron and Zinc Status
2017 · MMN group · Pregnant women aged 18–45 years with singleton pregnancies under 20 weeks in rural Gambia
400 mcg30 mg300 mcg400 IU4 mg184 days75