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Folic Acid and Zinc: study protocols

36 study groups took Folic Acid together with Zinc. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

36 study groups in 27 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 53% of 36 study groups.

Daily doseStudy groups
100 mcg or less
2
100 mcg to 250 mcg
10
250 mcg to 500 mcg
19
500 mcg to 1 mg
3
1 mg to 2.5 mg
0
over 2.5 mg
2

Dose per serving from research: Zinc

31 study groups in 25 studies say how much Zinc participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 10 mg to 25 mg, 39% of 31 study groups.

Daily doseStudy groups
2.5 mg or less
1
2.5 mg to 5 mg
4
5 mg to 10 mg
4
10 mg to 25 mg
12
25 mg to 50 mg
9
over 50 mg
1

Commonly used together

35 of 36 study groups took Folic Acid and Zinc with something else. Shown: what 3 or more different studies gave. The 10 most common of 14.

What was given together, not what works together.

Taken withStudy groups
Iron
30
Vitamin A
20
Vitamin B12
18
Vitamin C
15
Copper
14
Iodine
14
Vitamin D
14
Vitamin E
14
Selenium
13
Niacin
12

36 study groups

Study
Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial
2008 · Multiple micronutrients · Pregnant women resident in disadvantaged rural counties in Shaanxi Province, China; eligible women enrolled before 28 weeks’ gestation
400 mcg15 mg—1,899
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg15 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg15 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Folic acid + iron + zinc · Pregnant women in rural Nepal
400 mcg30 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
400 mcg30 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg2.14 mg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg15 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg15 mg180 days515
Maternal zinc supplementation and growth in Peruvian infants
2008 · zinc group · Pregnant women enrolled at 10–24 weeks of gestation; low-risk pregnancy
250 mcg15 mg—273
Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial
2002 · zinc sulfate and folic acid · Fertile and subfertile men
5 mg66 mg26 weeks—