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Folic Acid, Vitamin E and Vitamin B6: study protocols

13 study groups took Folic Acid together with Vitamin E and Vitamin B6. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

13 study groups in 10 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 62% of 13 study groups.

Daily doseStudy groups
100 mcg or less
1
100 mcg to 250 mcg
1
250 mcg to 500 mcg
8
500 mcg to 1 mg
3

Dose per serving from research: Vitamin E

13 study groups in 10 studies say how much Vitamin E participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mg to 10 mg, 54% of 13 study groups.

Daily doseStudy groups
2.5 mg or less
1
2.5 mg to 5 mg
1
5 mg to 10 mg
7
10 mg to 25 mg
2
25 mg to 50 mg
2

Dose per serving from research: Vitamin B6

13 study groups in 10 studies say how much Vitamin B6 participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 69% of 13 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
2
500 mcg to 1 mg
0
1 mg to 2.5 mg
9
2.5 mg to 5 mg
0
5 mg to 10 mg
0
10 mg to 25 mg
2

Commonly used together

13 of 13 study groups took Folic Acid, Vitamin E and Vitamin B6 with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.

What was given together, not what works together.

Taken withStudy groups
Vitamin B12
13
Vitamin A
12
Vitamin C
12
Copper
10
Iron
10
Niacin
10
Vitamin D
10
Zinc
10
Iodine
9
Riboflavin
9

13 study groups

Study
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg10 mg1.9 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg10 mg1.9 mg——
Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial
2016 · MMN group · Pregnant women aged at least 20 years, nulliparous, with Hb concentration ≥100 g/L and enrolled before 20 weeks of gestation
400 mcg10 mg1.9 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
400 mcg10 mg2.2 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin plus vitamin A · HIV-positive pregnant Tanzanian women
800 mcg30 mg25 mg——
Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension
2005 · Multivitamin without vitamin A · HIV-positive pregnant Tanzanian women
800 mcg30 mg25 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg1.43 mg271 mcg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg10 mg1.9 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg10 mg1.9 mg180 days515
Newborn micronutrient status biomarkers in a cluster-randomized trial of antenatal multiple micronutrient compared with iron folic acid supplementation in rural Bangladesh
2020 · MM · Pregnant women in rural Bangladesh; age range not specified; no disease condition specified
600 mcg15 mg1.9 mg—176