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Folic Acid, Vitamin E and Copper: study protocols

9 study groups took Folic Acid together with Vitamin E and Copper. These are the doses the studies gave. They are not a recommendation.

Folic Acid: what the research found →

Dose per serving from research: Folic Acid

9 study groups in 7 studies say how much Folic Acid participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 250 mcg to 500 mcg, 89% of 9 study groups.

Daily doseStudy groups
250 mcg to 500 mcg
8
500 mcg to 1 mg
1

Dose per serving from research: Vitamin E

9 study groups in 7 studies say how much Vitamin E participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 5 mg to 10 mg, 78% of 9 study groups.

Daily doseStudy groups
2.5 mg or less
1
2.5 mg to 5 mg
0
5 mg to 10 mg
7
10 mg to 25 mg
1

Dose per serving from research: Copper

9 study groups in 7 studies say how much Copper participants took a day.

These are the doses the studies gave. They are not a recommendation.

Most common: 1 mg to 2.5 mg, 78% of 9 study groups.

Daily doseStudy groups
500 mcg or less
1
500 mcg to 1 mg
1
1 mg to 2.5 mg
7

Commonly used together

9 of 9 study groups took Folic Acid, Vitamin E and Copper with something else. Shown: what 3 or more different studies gave. The 10 most common of 12.

What was given together, not what works together.

Taken withStudy groups
Iron
9
Vitamin A
9
Vitamin C
9
Vitamin D
9
Zinc
9
Iodine
8
Niacin
8
Selenium
8
Vitamin B12
8
Vitamin B6
7

9 study groups

Study
Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial
2008 · Multiple micronutrients · Pregnant women resident in disadvantaged rural counties in Shaanxi Province, China; eligible women enrolled before 28 weeks’ gestation
400 mcg10 mg2 mg—1,899
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · EMMS (early food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg10 mg2 mg——
Equity in adherence to and effect of prenatal food and micronutrient supplementation on child mortality: results from the MINIMat randomized trial, Bangladesh
2014 · UMMS (usual food invitation; multiple micronutrients) · Pregnant women in rural Bangladesh, enrolled before 14 weeks’ gestation
400 mcg10 mg2 mg——
Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal
2003 · Multiple micronutrients · Pregnant women in rural Nepal
400 mcg10 mg2 mg——
Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam
2017 · MM (multiple micronutrients) preconception group · Women of reproductive age in Vietnam intending to become pregnant
400 mcg1.43 mg286 mcg54 weeks1,469
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-180 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg10 mg2 mg180 days516
Assessing the adherence and acceptability to iron and folic acid compared with multiple micronutrient supplements during pregnancy: a cluster-randomized noninferiority trial in Cambodia
2025 · MMS-90 · Healthy pregnant individuals aged 18–45 years, in the first 14 weeks of a low-risk singleton pregnancy
400 mcg10 mg2 mg180 days515
Antenatal Multiple Micronutrient Supplementation Compared to Iron-Folic Acid Affects Micronutrient Status but Does Not Eliminate Deficiencies in a Randomized Controlled Trial Among Pregnant Women of Rural Bangladesh
2019 · MM · Pregnant women aged 12–45 years in rural Bangladesh
600 mcg15 mg1 mg165 days749
A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia
2019 · UNIMMAP tablet · Nonpregnant, non-lactating healthy women aged 18–45 years in West Kiang, The Gambia; women of reproductive age with common micronutrient deficiencies in the population
400 mcg10 mg2 mg12 weeks105
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